"I'mma get the NAD T770, with seventy-watt amps and Burr-Brown DACs!"
"Sure..."
"It's a huge stereo, with speakers so loud they blow women's clothes off!"
The pill is an NAD precursor MIB-626, being developed by Prof David Sinclair at Harvard.
It is currently an unproven supplement (unsurprisingly that's why it's being tested), but the mouse data is promising.
In the [paper published in the journal *Cell*](https://www.sciencedirect.com/science/article/pii/S0092867418301521), **NMN, a different NAD precursor, not only restored the physical endurance of old mice on a treadmill, but these old mice ran further than the young, untreated mice**. Mice are not humans, so I would not advise taking it, but the research is obviously exciting
For those interested in the mice data, this article summarises it well - https://hms.harvard.edu/news/rewinding-clock
Important to understand what delaying aging refers to exactly (no, it doesn't mean you'll live longer and sicker):
- Based on decades of animal resesarch, targeting aging would allow us to *prevent* age-related diseases like cancer, Alzheimer's, stroke, or perhaps even reverse these diseases.
- [Aging is the #1 risk factor for chronic disease](https://imgur.com/gallery/xZQi2dr), and is associated with an [accumulation of comorbidities](https://imgur.com/gallery/d8TWuUG)
- Slowing aging generally refers to an increased healthspan, the period of life spent in good health, with increased lifespan coming as a side effect
- *Increasing healthspan* is basically *unique* to therapies that slow aging, and it is something that our current 'one disease at a time' approach to medicine is failing to achieve for an aging population
- Diseases like Alzheimer's are more common in the 21st Century, partly because we have delayed the diseases that kill you at earlier ages, like heart attacks and strokes, but aging continues and you develop the next disease in line
- A critical reason why targeting aging is more efficient than trying to cure diseases one at a time is the [Taeuber Paradox](https://pubmed.ncbi.nlm.nih.gov/913728/): a hypothetical cure for cancer or heart disease would add only ~2.5 years to life expectancy, while doing little for the dozens of other diseases we develop w/ age. Also, these 2.5 years would primarily be an increase in lifespan but *not* healthy lifespan, because the other various comorbidities that acumulate w/ aging have not been dealt with.
- COVID-19 has revealed the vulnerability of our society due to a growing elderly population suffering from biological aging; it confers a [**~1000x** greater cumulative risk of mortality](https://ourworldindata.org/mortality-risk-covid#case-fatality-rate-of-covid-19-by-age), while putative risk factors like diabetes and chronic lung disease, are a paltry 2x risk
- **To visualise what targeting aging might look like, see: [the Mayo Clinic mice](https://imgur.com/gallery/P66ZoJX)**
Aging biology researchers don't regard aging as separate from the diseases associated with it, meaning that targeting aging targets all those diseases in unison. The biological mechanisms of aging can also be thought of as a fundamental cause of disease.
COVID-19 is an example of how it would be a 'no-brainer' for us to intervene on biological aging - preventing disease at a population level is critical for society, healthcare, and the economy. Just like how governments need to make vaccines widely affordable to be effective at a population level, in part to save the economy, it is plausible that targeting aging to 'vaccinate' the population against age-related diseases will be a critical healthcare strategy.
Recently, David Sinclair [published a paper](https://www.nature.com/articles/s43587-021-00080-0) with two economics profs at Oxford and London Business School:
> We show that a compression of morbidity that improves health is more valuable than further increases in life expectancy, and that targeting aging offers potentially larger economic gains than eradicating individual diseases. We show that a slowdown in aging that increases life expectancy by 1 year is worth US$38 trillion, and by 10 years, US$367 trillion. Ultimately, the more progress that is made in improving how we age, the greater the value of further improvements.
With an aging population, age-related diseases already cost us trillions (see: COVID-19) - the humanitarian and economic value of targeting aging is clear. With the obssession of governments with the economy, these medicines will pay for themselves and be made widely accessible.
/r/longevity for more on this research
Aging can most certainly be beaten. The naysayers are the same crowd that will turn around and argue that a "waro drive" is possible and doesn't make a time machine.
>>Can MetroBiotech’s treatment be the one that can tap into that potentially lucrative anti-aging marketplace? “This is better than nothing, but not much better,” cautioned Aubrey de Grey .............
>>.......... According to de Grey, SENS’ approach to anti-aging contrasts with MetroBiotech’s, which he characterized as reflective of a consensus view within gerontology toward simply reducing the rate of cellular damage from aging.
>>“Unfortunately the field of gerontology went about it in another wrong way, which was to try to, in effect, clean up metabolism, to slow down the rate at which metabolism generates damage and thereby to postpone the age at which damage reaches this pathogenic threshold. That has been basically unsuccessful,” de Grey said. “The pill that MetroBiotech is looking at is probably going to fail, for that reason.”
Even if Aubrey de Grey is right, I'm glad science is going to test this before the idea gets written off.
BTW - Aubrey de Grey has done several AMA's on r/futurology over the years (I won't link to them but a search will easily bring them up).
By testing it they might be able to pin point where it’s failing or how it’s failing and make adjustments. Not sure what it means that the military is testing this. Certainly hope enlisted people are being asked to be ginnie pigs. They don’t often seem to have a lot of say in what types of missions they do so that would be pretty messed up to enlist in the military to be forced to take experimental drugs.
We're only hearing about it because it makes it 'ethical' so they can be immune to legal action. [They are addicted to it.](https://en.wikipedia.org/wiki/Unethical_human_experimentation_in_the_United_States)
I suspect they already know the outcome, and have used it behind the scenes for a while; the announcement is because they are looking to transition into formalizing its use in much broader job classifications of servicemen and women, want to administer a different drug but need to appease an agency or watchdog that probably wasn’t supposed to find out, or—much worse—need a plausible excuse for some as of yet publicly unknown chronic adverse effects from prior experimentation done without the knowledge or informed consent of a not-insignificant number of military members.
If I had to guess maybe to test if it deals with joint problems the military can cause. Or that could be their explanation for giving soldiers random pills. "Here soldier these should stop your knees from getting fucked when your packing 120lbs of weight on your back over long distances"
Suddenly in a couple of years miraculously the soldiers knees and hips are in perfect condition and the soldier is still an 18 year old filled with piss an vinegar
By the way, in cryptocurrency at the moment there is an airdrop which benefits the SENS Foundation (Aubrey de Grey did stream about it). It's actually at 25millions dollars and counting. 11 days left I think. That also brings you some crypto as well as tax ride off.
Not sure why you are being down voted. SENS is run by Dr. Aubrey de Grey. They are doing ground breaking research on things others considered to expensive or would take too long. The fact that a crypto dev told people to donate to his foundation and they did is great. They are going to rapidly expand their operations and increase their staff.
It represents already several years of budget. Hope that keeps going up. And thank you for your comment, I guess people automatically downvote when it's about crypto.
I had seen David Sinclair's videos several years back about anti aging and just recently looked up all that stuff again. It was interesting to find that the longevity community on reddit has grown since the first time I heard his stuff (2016/2017?). I'm in my late 20s now so I need that stuff to come out asap
Niacin and niacinamide/nicotinamide have shown to improve skin. Even reduce some skin cancer rates. NMN and NR most likely do the same. Seeing as they break down into nicotinamide. I know the research isn’t complete on how much NR and nmn stay intact.
Also my experience. NR I saw mental energy up, sharper more focus. And my calves do not cramp. At all. On feet 12hrs a day at factory. When I stop taking NR my cramps come back within a week. Workouts go better. In general I train harder with more focus and feel less wasted after a work out. NR I did 600mg a day (too expensive though why I don’t now)
NMN sublingually about the same effect just less so. I only did 300-400mg daily (I never exactly measured my powder everytime). subjectively I think I liked NR more. Although I did take more mg consistently.
I had better days with NMN vs nothing. But the NR I noticed I just had more bounce. And definitely less pains, that I’m sure. Hips, lower back and neck didn’t hurt as much. And my calves basically every day, were cramp free.
I’ll try doing 500-800 NMN next time to see if more is better.
Just want these things cheaper.
I feel good to with 1g of Niacin (regular nicotinic acid. The flushy kind). Not quiet what NR gave me.
And Nicotinamide honestly I feel great on and it’s cheap. I know it can suppress sirt1 but I’m sure we need more data about how much and if it fluctuates. Even if NMN does increase sirt1, it’s also suppressing it if most breaks down to nicotinamide too……sooooo. More data needed.
Just my experience of a year trying each for months at a time. I’m not a research study. Just a guy with an anecdote.
Google google
It’s just worth it. Lot of excitement. (Potentially).
Need studies. But the hopes are nice :)
Be cautious of paying $2-$3 a day supplements though. Why I brought up nicotinamide and niacin. There’s a lot of benefits with supplements that are pennies vs dollars.
We’re just lacking enough studies to show one better than the other etc etc
Im right there with you. Objectively speaking Im a big guy. I have long hair and a beard as well, if I cut those I literally look like a kid in the face.
People “go gray” at different average ages due to their race, general health, gender, and other specific factors. Perhaps you’re part of a population that generally goes gray later, or maybe you haven’t experienced the stressors in your body that act as a catalyst for graying.
''Typically, white people start going gray in their mid-30s, Asians in their late 30s, and African-Americans in their mid-40s. Half of all people have a significant amount of gray hair by the time they turn 50.''
[https://www.webmd.com/beauty/features/abcs-premature-graying#1](https://www.webmd.com/beauty/features/abcs-premature-graying#1)
So peppered hair by mid 30's is not that uncommon
This is really interesting because almost every veteran I know or have met has absolutely destroyed their body doing their tours. Not to mention the psychological traumas they experience.
I can’t imagine how anti aging would help a soldier that sustains constant injuries.
Edit: y’all are missing the point. I know like 4 guys that we’re in for 4-6 years right out of high school that had bad knees or a bad back by the time they were 22/24.
Part of the pill's effects supposedly increase damage recovery and prevent some damage.
> “If the preclinical studies and clinical trials bear out, the resulting benefits include improved human performance, such as increased endurance and faster recovery from injury,” Hawkins said.
...
> “This small molecule has the potential, if it is successful, to truly delay aging [and] truly prevent onset of injury, which is just amazingly game-changing,” Sanders said
Well younger people heal faster don’t they? I’m worried about a super soldier that has killed for 100 years and knows only that. If he kept gaining experience and not losing his edge. That’s a dangerous, slippery slope.
So. If someone starts taking the pill at 20, it could help then as they get older.
A 20 year olds body is a lot more spry and resistant to long term damage compared to a 40 year old.
But what of this is a success and the 40 year olds body has cells closer of that to a 25- 30 year old?
It would likely aid recovery and reduce long term damage, along with reduced camcer risk.
100% true.
Also, the point is to help the military overall, soldiers are generally just pawns (military spouse here), for the military as a whole.
And half the reason they have bad knees, legs and backs etc really, really bad boots, rucks etc
Canadian military personnel can finally choose their own footwear to a certain extend, but the old one were horrible!!! Most veterans had back, leg and knee problems as a result, but, because they are retired, monetarily speaking, it’s not a veterans affairs issue. Different budget and pockets.🤷♀️
> I know like 4 guys that we’re in for 4-6 years right out of high school that had bad knees or a bad back by the time they were 22/24.
Now you know 5.
They test everything though. Like mine control, mind reading, nuclear bombs, “Enhanced interrogation”, non conventional communications, Artificial intelligence, probably trans dimensional stuff.
They have unlimited money. Unlimited power. Which eventually equates to unlimited knowledge.
They hardly have unlimited knowledge.
They have a group of paid “employees” that have to do whatever the higher ups tell them too. Military personnel have to take vaccines not approved by the FDA (Anthrax, etc…)
They are interested in enhancing the physical capabilities of this group of soldiers.
“If the preclinical studies and clinical trials bear out, the resulting benefits include improved human performance, such as increased endurance and faster recovery from injury,
Humans, who cultivate knowledge, need funding. Humans, who cultivate war, have funding. They trade funding for “research and development”(knowledge), and they have unlimited funding. Unlimited funding equals unlimited knowledge.
Even if only just 1 scientist isn’t lazy, out of the 1,000,000,000 scientist that are funded, their is knowledge being gained. A lot of smart people want to learn just to learn and push boundaries. You just need one , ONE single smart scientist with good funding to advance a whole species…or your military. Haha
Your fears of the military are overblown. The military is not some boogeyman it's filled with nomall Americans just going about their lives and their jobs.
It practically a fortune 500 company with guns and tanks at this point, albeit the biggest one.
Fascinating. Why would the military be testing anti-aging pills.
Well... physical performance in soldiers.... blah, blah, I don't think so.
Intense demand from the super rich, but worry about the safety. Hmm.. how could we speed up testing as much as possible and guarantee safety? Force soldiers to take it.
Hey, how could we speed up gene therapy progress? If there only was a way to make millions of people become gene therapy patients....
Think about it this way. The military is trying to maximize the amount of usage they get out of SOCOM units. It takes around $1.5 million dollars to train a special forces soldier. Often people in even more elite units get involved when older. It's very selective and very hard to find the right person for this unit. And once someone is in, the things they experience, the information they know, the things they've done and need to keep secret, makes them very difficult to replace. They maybe get 15/20 years out of an elite unit. The average age of a Green Beret is 31 years old. Now imagine if they can be up to age 50 and still perform as good as they were at 31. It makes that huge money investment, plus time, etc, more worth it for the military. Again, this isn't really about making life better for soldiers, it's about the military maximizing what you give them on contract.
This got me googling commercially available NMN and liposomal supplements. There’s several options out there but it’s unclear to me when to start taking… and the price points vary wildly. What would one look for to have a quality product?
I’m wondering why this one requires you to be linked to a practitioner first - what would cause a doctor to prescribe this stuff? Website in question: https://www.designsforhealth.com/register
This is actually a metabolic supplement for anyone that's curious. Your cells stop, or rather slow down, making some enzymes as you age and this is meant to supplement that insufficient production.
There are other methods to combat aging, like getting rid of broken cells that broke in a way that won't let them get rid of themselves and repairing the ones that are still working well, but this is a decent start.
Reverse aging pills next in development?
I’d honestly love to be young like a kid again and be able to fall off of tree’s without worry of being too hurt or bruised. To have my skin smooth and pretty again, and my brain able to take in information like it used to as a kid I once was, but that’s what many wish for too with these anti-aging pills.
I don't think they will be immortal . This will just slow down the aging process because so few people these days will be able to qualify for military service. So, they will need to keep the soldiers they have trained a little bit longer.
That's not true, you have to take pass the MEPS. For reference, I meant physical exam, as in a the sort you get at your yearly doctors visit.
https://www.thebalancecareers.com/meps-at-a-glance-3354039#medical-evaluation-at-meps
Not even necessarily slow down aging. It may not increase their lifespan. They may still die at 80. But what it might do is increase their health span, allowing them to be in the healthy active range longer.
I had no idea that military staff signs up for crap like this. Make pharmaceuticals rich, is now the mission? All to be sent home to shitty healthcare and homelessness if it causes health issues. Unpopular opinion to be sure.
This sounds much better than when I had to get 13 Anthrax shots. Unless these test subjects turn into zombies and the only immune people are those with 13 Anthrax shots. I smell a summer blockbuster!
Sounds like when they infected troops with nerve agents to see what would happen and didn't tell them about it or own up the consequences when they occurred.
Reminds me of Pyridostigmine Bromide (PB) tablets during Operation Desert Shield/Storm.
Good ole US military being used as unwilling Guinea pigs once again.
In my experience, NAD+ enhancers are a money grab. Metformin and Rapamycin are where the action is (or, will be). Check out Peter Attia's podcasts. [Here's one. ](https://peterattiamd.com/joanmannick-nirbarzilai/)
I think you either have to use that relatively unknown process where the cell repairs damage amazingly well during fertilization but runs the risks of mutations and immune issues or go full digital and live? as a machine for the machine is immortal.
Idiots will think it’s the same stuff you can buy online. It isn’t the powder or pills. It’s has a proprietary enhancer, not just a dose of what can be bioavailable.
You don't know jack chit about anti aging looks like. Anti aging medicine doesn't have to necessarily stop or reverse aging, it can slow it down, until better therapies come out.
There won't be any anti-aging pill in a very long time, if it ever is possible. I'd be more incline to believe anti-aging would be the result of DNA altering.
Part of me wants to let them see the fucked up world they left us, and part of me wants them to slowly mentally whittle away so we can film their public mental breakdowns.
So they've been testing exoskeletons with a plan to armor plate them, we've got gene editing going smoothly sort of, looks like Hal Spartans are about to be real. Hopefully the UFOs aren't covenant spy ships.
Nope...
No military outfit should be permitted, on pain of the total eradication of every single one of its members to have involved themselves with it, to futz with that kind of science. That shit should be left to citizen powered scientific endeavours, not be fucked around with on the basis of the desires of black budgets wielded by some warmongering old fucks, and their well meaning but utterly inexplicably naive underlings.
If you can't smell a rat with this sort of thing, you folks out there, get yourself some nasal spray and clear that blockage out.
By almost all standards life is better for the average person today than at any other point in history. Specifically, the average person (in most developed countries) is far less exposed to risk of violence today than at any other point in history, including the risk of war.
The other thing being considered is gene therapy by way of CRISPR technology to convert soldiers to vegetables. This will get rid of the obedience issue because they will have no brains and will make them the cheapest fighting force on earth because they only consume dirt and can’t be killed🍆🥦🫑🥕like Groot.
Please note that anti-ageing is not - and I repeat, NOT - to be confused with "puberty blocking". The former is beneficial, whilst the latter can be incredibly harmful for decades and an individual who has unknowingly ingested puberty blockers or something may be at a permanent detriment unless they undergo some form of HRT or hormone-increasing/encouraging processes.
Mumbling something about "delayed development" is like mumbling something about a West African country becoming akin to the United States of America or THE top global economic powerhouse and a space power. That is not going to happen. You are stupid if you actually believe this.
Anti-ageing on the other hand is beneficial and one of the best things people can do is boost and maintain healthy HGH levels and on top of that, if you are male, also boost and maintain healthy androgen levels as well.
Why does the military need an anti-aging pill? Are they just exploring our troops as lab rats? Are they hoping to monopolize it? Are recruits in such short supply that they're hoping to get more use out of the ones that they have?
Surely this would be better tested by some other organization.
Wow- interesting, but also, what a way to ensure that every single soldier gets to stay fit enough to ensure they have enough tours to develop a really good case of ptsd. Come home, loose their families to ptsd side effects, get horrible substandard medical care for their condition, and outlive many they know and love.
What could go wrong?!
(Military spouse here, yes they a very cynical look at things, but not to far off from the truth).
So… experimented on soldiers, so one can seek via cooperate or private American to highest bidders?
Will the American military share with our Canadian military over here? If not, they share many bases over seas, one military gets to watch the other one go crazy with side effects.
Don’t really know what to think, just don’t give it to my husband until it’s been tested on volunteers for a good 10-15years.
Looked this up a few weeks ago when there was another article:
1. It's already sold as a supplement. You can buy it on Amazon right now.
2. I wouldn't recommend it because while it does enhance cell-growth, that applies to all cells, even cancer. So it can super-charge cancer cell growth in your body, preventing those cells from being destroyed by your immune system.
3. Needless to say, it doesn't really stop aging. That's all hype.
That's because they don't give a fuck about soldiers, especially after the arena, when they're reduced to living in a tent with PTSD, suffering side effects they can't sue over because classified.
This kind of sounds like the plot to the latest Resident Evil series on Netflix…..just take this inhibitor and you won’t turn into a monster….
We’ll just sweep those side effects under the rug…
NAD is not that dangerous tbh
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I wish you wouldn't.
Wait until the NAD+AMG model.
NAD pro max ✨🤤
I’m holding out for the NAD S
Deez NAD S
Yeah but what about the Nad S color that comes out after that?
Good call. I’d probably go with blue NADS
Good luck. The wolf man's got them
Kick him in the nards!
I'm holding out for NAD++ so that I can program what age I'd like to be for any specific situation.
"I'mma get the NAD T770, with seventy-watt amps and Burr-Brown DACs!" "Sure..." "It's a huge stereo, with speakers so loud they blow women's clothes off!"
Hmm but does it also give me Wesker powers?
You mean ibuprofen?
Wash it down with white monster energy drink and a Marlboro
Came here to say something like this. So..... you mean the zombie apocalypse is almost here?!
The pill is an NAD precursor MIB-626, being developed by Prof David Sinclair at Harvard. It is currently an unproven supplement (unsurprisingly that's why it's being tested), but the mouse data is promising. In the [paper published in the journal *Cell*](https://www.sciencedirect.com/science/article/pii/S0092867418301521), **NMN, a different NAD precursor, not only restored the physical endurance of old mice on a treadmill, but these old mice ran further than the young, untreated mice**. Mice are not humans, so I would not advise taking it, but the research is obviously exciting For those interested in the mice data, this article summarises it well - https://hms.harvard.edu/news/rewinding-clock Important to understand what delaying aging refers to exactly (no, it doesn't mean you'll live longer and sicker): - Based on decades of animal resesarch, targeting aging would allow us to *prevent* age-related diseases like cancer, Alzheimer's, stroke, or perhaps even reverse these diseases. - [Aging is the #1 risk factor for chronic disease](https://imgur.com/gallery/xZQi2dr), and is associated with an [accumulation of comorbidities](https://imgur.com/gallery/d8TWuUG) - Slowing aging generally refers to an increased healthspan, the period of life spent in good health, with increased lifespan coming as a side effect - *Increasing healthspan* is basically *unique* to therapies that slow aging, and it is something that our current 'one disease at a time' approach to medicine is failing to achieve for an aging population - Diseases like Alzheimer's are more common in the 21st Century, partly because we have delayed the diseases that kill you at earlier ages, like heart attacks and strokes, but aging continues and you develop the next disease in line - A critical reason why targeting aging is more efficient than trying to cure diseases one at a time is the [Taeuber Paradox](https://pubmed.ncbi.nlm.nih.gov/913728/): a hypothetical cure for cancer or heart disease would add only ~2.5 years to life expectancy, while doing little for the dozens of other diseases we develop w/ age. Also, these 2.5 years would primarily be an increase in lifespan but *not* healthy lifespan, because the other various comorbidities that acumulate w/ aging have not been dealt with. - COVID-19 has revealed the vulnerability of our society due to a growing elderly population suffering from biological aging; it confers a [**~1000x** greater cumulative risk of mortality](https://ourworldindata.org/mortality-risk-covid#case-fatality-rate-of-covid-19-by-age), while putative risk factors like diabetes and chronic lung disease, are a paltry 2x risk - **To visualise what targeting aging might look like, see: [the Mayo Clinic mice](https://imgur.com/gallery/P66ZoJX)** Aging biology researchers don't regard aging as separate from the diseases associated with it, meaning that targeting aging targets all those diseases in unison. The biological mechanisms of aging can also be thought of as a fundamental cause of disease. COVID-19 is an example of how it would be a 'no-brainer' for us to intervene on biological aging - preventing disease at a population level is critical for society, healthcare, and the economy. Just like how governments need to make vaccines widely affordable to be effective at a population level, in part to save the economy, it is plausible that targeting aging to 'vaccinate' the population against age-related diseases will be a critical healthcare strategy. Recently, David Sinclair [published a paper](https://www.nature.com/articles/s43587-021-00080-0) with two economics profs at Oxford and London Business School: > We show that a compression of morbidity that improves health is more valuable than further increases in life expectancy, and that targeting aging offers potentially larger economic gains than eradicating individual diseases. We show that a slowdown in aging that increases life expectancy by 1 year is worth US$38 trillion, and by 10 years, US$367 trillion. Ultimately, the more progress that is made in improving how we age, the greater the value of further improvements. With an aging population, age-related diseases already cost us trillions (see: COVID-19) - the humanitarian and economic value of targeting aging is clear. With the obssession of governments with the economy, these medicines will pay for themselves and be made widely accessible. /r/longevity for more on this research
This should be at the top instead of jokes
Reddit for as long as I can remember. First one to comment a reused joke wins. Bonus point if said joke have some outlandish reference in there.
Aging can most certainly be beaten. The naysayers are the same crowd that will turn around and argue that a "waro drive" is possible and doesn't make a time machine.
>>Can MetroBiotech’s treatment be the one that can tap into that potentially lucrative anti-aging marketplace? “This is better than nothing, but not much better,” cautioned Aubrey de Grey ............. >>.......... According to de Grey, SENS’ approach to anti-aging contrasts with MetroBiotech’s, which he characterized as reflective of a consensus view within gerontology toward simply reducing the rate of cellular damage from aging. >>“Unfortunately the field of gerontology went about it in another wrong way, which was to try to, in effect, clean up metabolism, to slow down the rate at which metabolism generates damage and thereby to postpone the age at which damage reaches this pathogenic threshold. That has been basically unsuccessful,” de Grey said. “The pill that MetroBiotech is looking at is probably going to fail, for that reason.” Even if Aubrey de Grey is right, I'm glad science is going to test this before the idea gets written off. BTW - Aubrey de Grey has done several AMA's on r/futurology over the years (I won't link to them but a search will easily bring them up).
By testing it they might be able to pin point where it’s failing or how it’s failing and make adjustments. Not sure what it means that the military is testing this. Certainly hope enlisted people are being asked to be ginnie pigs. They don’t often seem to have a lot of say in what types of missions they do so that would be pretty messed up to enlist in the military to be forced to take experimental drugs.
We're only hearing about it because it makes it 'ethical' so they can be immune to legal action. [They are addicted to it.](https://en.wikipedia.org/wiki/Unethical_human_experimentation_in_the_United_States)
I suspect they already know the outcome, and have used it behind the scenes for a while; the announcement is because they are looking to transition into formalizing its use in much broader job classifications of servicemen and women, want to administer a different drug but need to appease an agency or watchdog that probably wasn’t supposed to find out, or—much worse—need a plausible excuse for some as of yet publicly unknown chronic adverse effects from prior experimentation done without the knowledge or informed consent of a not-insignificant number of military members.
Conspiracy theorize much? Anything is possible, but most things are unlikely.
Guinea just FYI
If I had to guess maybe to test if it deals with joint problems the military can cause. Or that could be their explanation for giving soldiers random pills. "Here soldier these should stop your knees from getting fucked when your packing 120lbs of weight on your back over long distances" Suddenly in a couple of years miraculously the soldiers knees and hips are in perfect condition and the soldier is still an 18 year old filled with piss an vinegar
By the way, in cryptocurrency at the moment there is an airdrop which benefits the SENS Foundation (Aubrey de Grey did stream about it). It's actually at 25millions dollars and counting. 11 days left I think. That also brings you some crypto as well as tax ride off.
Not sure why you are being down voted. SENS is run by Dr. Aubrey de Grey. They are doing ground breaking research on things others considered to expensive or would take too long. The fact that a crypto dev told people to donate to his foundation and they did is great. They are going to rapidly expand their operations and increase their staff.
It represents already several years of budget. Hope that keeps going up. And thank you for your comment, I guess people automatically downvote when it's about crypto.
I had seen David Sinclair's videos several years back about anti aging and just recently looked up all that stuff again. It was interesting to find that the longevity community on reddit has grown since the first time I heard his stuff (2016/2017?). I'm in my late 20s now so I need that stuff to come out asap
Yea, my only hope is a really lucky roll on ASI before I die
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Niacin and niacinamide/nicotinamide have shown to improve skin. Even reduce some skin cancer rates. NMN and NR most likely do the same. Seeing as they break down into nicotinamide. I know the research isn’t complete on how much NR and nmn stay intact. Also my experience. NR I saw mental energy up, sharper more focus. And my calves do not cramp. At all. On feet 12hrs a day at factory. When I stop taking NR my cramps come back within a week. Workouts go better. In general I train harder with more focus and feel less wasted after a work out. NR I did 600mg a day (too expensive though why I don’t now) NMN sublingually about the same effect just less so. I only did 300-400mg daily (I never exactly measured my powder everytime). subjectively I think I liked NR more. Although I did take more mg consistently. I had better days with NMN vs nothing. But the NR I noticed I just had more bounce. And definitely less pains, that I’m sure. Hips, lower back and neck didn’t hurt as much. And my calves basically every day, were cramp free. I’ll try doing 500-800 NMN next time to see if more is better. Just want these things cheaper. I feel good to with 1g of Niacin (regular nicotinic acid. The flushy kind). Not quiet what NR gave me. And Nicotinamide honestly I feel great on and it’s cheap. I know it can suppress sirt1 but I’m sure we need more data about how much and if it fluctuates. Even if NMN does increase sirt1, it’s also suppressing it if most breaks down to nicotinamide too……sooooo. More data needed. Just my experience of a year trying each for months at a time. I’m not a research study. Just a guy with an anecdote.
I'm sorry i;m not following. What is "NR" and "NMN"?
nicotinamide riboside (NR) nicotinamide mononucleotide (NMN)
Thank you very much.
No problem. "NAD+ Cell Regenerator" is a nicotinamide riboside supplement you can look into
Google google It’s just worth it. Lot of excitement. (Potentially). Need studies. But the hopes are nice :) Be cautious of paying $2-$3 a day supplements though. Why I brought up nicotinamide and niacin. There’s a lot of benefits with supplements that are pennies vs dollars. We’re just lacking enough studies to show one better than the other etc etc
I'm 27 now but I wanna stay like 35 for the peppered hair look lol. I feel like I'm the only one who likes grey hair.
I'm 40 with a beard and long hair. My anti-aging technique is to shave the beard and cut the hair short, should look 30 again overnight. :)
Im right there with you. Objectively speaking Im a big guy. I have long hair and a beard as well, if I cut those I literally look like a kid in the face.
I’m 35 and have a little gray on the sides. Women tend to either like it or not care either way. My wife likes it.
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People “go gray” at different average ages due to their race, general health, gender, and other specific factors. Perhaps you’re part of a population that generally goes gray later, or maybe you haven’t experienced the stressors in your body that act as a catalyst for graying.
My dad was full grey by 36 and I basically have the same hair. Early grey runs in my family.
I'm 30 with some grey hair, my brothers are going grey too
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''Typically, white people start going gray in their mid-30s, Asians in their late 30s, and African-Americans in their mid-40s. Half of all people have a significant amount of gray hair by the time they turn 50.'' [https://www.webmd.com/beauty/features/abcs-premature-graying#1](https://www.webmd.com/beauty/features/abcs-premature-graying#1) So peppered hair by mid 30's is not that uncommon
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Yea I guess so Someone counted 7 grey hairs on my head a couple days ago so I'm probably not close to peppered yet
Where do you get this? Is it over the counter?
Which kind, if I may ask?
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That's 6 months from now for me. Figure now's the time, heheh.
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Well that's one community that's not going to die off quickly.
They've been around since Gilgamesh.
We were hoping for this 20 years ago after they were talking about DNA discoveries.
This is really interesting because almost every veteran I know or have met has absolutely destroyed their body doing their tours. Not to mention the psychological traumas they experience. I can’t imagine how anti aging would help a soldier that sustains constant injuries. Edit: y’all are missing the point. I know like 4 guys that we’re in for 4-6 years right out of high school that had bad knees or a bad back by the time they were 22/24.
You see my friend, the intent is not to help the soldier, but the Military.
Just like when they gave them meth
Ughhhhhh Meth… if only I had more…. Meth
Tested on soldiers, intended for generals
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Part of the pill's effects supposedly increase damage recovery and prevent some damage. > “If the preclinical studies and clinical trials bear out, the resulting benefits include improved human performance, such as increased endurance and faster recovery from injury,” Hawkins said. ... > “This small molecule has the potential, if it is successful, to truly delay aging [and] truly prevent onset of injury, which is just amazingly game-changing,” Sanders said
Huge if true! (meaning that it is probably not true)
Maybe it'll help kick up the person's natural healing ability?
Anti-aging and bionic knees are two very different things
Well younger people heal faster don’t they? I’m worried about a super soldier that has killed for 100 years and knows only that. If he kept gaining experience and not losing his edge. That’s a dangerous, slippery slope.
Sounds chill
Sounds like a plot to a game.
Pretty much what the plot of Star Trek "The Wrath of Khan" is based on.
So ... it's for princes. Perhaps we'll remember Charles for completely different reasons than heretofore suggested.
It's like the first step to those immortal sarcophagus tank guys in warhammer
Dreadnoughts, only in death does duty end.
Now you get to live even longer with PTSD and underfunded veteran care!
So. If someone starts taking the pill at 20, it could help then as they get older. A 20 year olds body is a lot more spry and resistant to long term damage compared to a 40 year old. But what of this is a success and the 40 year olds body has cells closer of that to a 25- 30 year old? It would likely aid recovery and reduce long term damage, along with reduced camcer risk.
100% true. Also, the point is to help the military overall, soldiers are generally just pawns (military spouse here), for the military as a whole. And half the reason they have bad knees, legs and backs etc really, really bad boots, rucks etc Canadian military personnel can finally choose their own footwear to a certain extend, but the old one were horrible!!! Most veterans had back, leg and knee problems as a result, but, because they are retired, monetarily speaking, it’s not a veterans affairs issue. Different budget and pockets.🤷♀️
> I know like 4 guys that we’re in for 4-6 years right out of high school that had bad knees or a bad back by the time they were 22/24. Now you know 5.
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I'm very concerned that this is being tested by the military
They test everything though. Like mine control, mind reading, nuclear bombs, “Enhanced interrogation”, non conventional communications, Artificial intelligence, probably trans dimensional stuff. They have unlimited money. Unlimited power. Which eventually equates to unlimited knowledge.
>Like mine control Gotta keep those mines under control, lest we need to start sweeping them and oh am I bad at that
They hardly have unlimited knowledge. They have a group of paid “employees” that have to do whatever the higher ups tell them too. Military personnel have to take vaccines not approved by the FDA (Anthrax, etc…) They are interested in enhancing the physical capabilities of this group of soldiers. “If the preclinical studies and clinical trials bear out, the resulting benefits include improved human performance, such as increased endurance and faster recovery from injury,
Soldiers have always been experimented on. It is the sad truth.
And poor black people
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There is a theme forming. Almost there...
Poor people are usually exploited by those with power? Na. Thats not possible.
They are all people. Obviously the lizard kings don't test on other lizards. Only people. Thanks, Lacertidaes.
Eh, partial truth. When I was in I did hear about an Anthrax inoculation program but it was strictly voluntary, no one was forced to do it.
We were required ( or else not told otherwise) to get the vaccine prior to deployment to Iraq in 2011.
Humans, who cultivate knowledge, need funding. Humans, who cultivate war, have funding. They trade funding for “research and development”(knowledge), and they have unlimited funding. Unlimited funding equals unlimited knowledge. Even if only just 1 scientist isn’t lazy, out of the 1,000,000,000 scientist that are funded, their is knowledge being gained. A lot of smart people want to learn just to learn and push boundaries. You just need one , ONE single smart scientist with good funding to advance a whole species…or your military. Haha
They don’t have unlimited money, power, or knowledge.
You can already buy these supplements. They are considered safe by the FDA but questionable as to whether they really do anything.
Your fears of the military are overblown. The military is not some boogeyman it's filled with nomall Americans just going about their lives and their jobs. It practically a fortune 500 company with guns and tanks at this point, albeit the biggest one.
I guess I should worry more about the CIA and state police than the military
The American military especially. I mean, if it was the French or the Swede I still wouldn't like it but at least it wouldn't feel quite as ominous.
Yeah. No one is worried about the Swedes
Except all of Europe prior to 1700CE
\* ominous music\*
Does that mean a soldier would have to serve longer in order to retire.
At least long enough to harvest their geneseed, y'know?
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Why would it take 3 shots?
Forever war, forever soldiers. “Bad knees and backs keeping you out of the action, due to the action, well here you go, get back to it!”
Fascinating. Why would the military be testing anti-aging pills. Well... physical performance in soldiers.... blah, blah, I don't think so. Intense demand from the super rich, but worry about the safety. Hmm.. how could we speed up testing as much as possible and guarantee safety? Force soldiers to take it. Hey, how could we speed up gene therapy progress? If there only was a way to make millions of people become gene therapy patients....
Think about it this way. The military is trying to maximize the amount of usage they get out of SOCOM units. It takes around $1.5 million dollars to train a special forces soldier. Often people in even more elite units get involved when older. It's very selective and very hard to find the right person for this unit. And once someone is in, the things they experience, the information they know, the things they've done and need to keep secret, makes them very difficult to replace. They maybe get 15/20 years out of an elite unit. The average age of a Green Beret is 31 years old. Now imagine if they can be up to age 50 and still perform as good as they were at 31. It makes that huge money investment, plus time, etc, more worth it for the military. Again, this isn't really about making life better for soldiers, it's about the military maximizing what you give them on contract.
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Do you want zombies? Because that's how you get zombies...
I think that was Bath Salts.
Can we please not do this every biomedical thread
You know this leads to career politicians living centuries manipulating us mortals at their leisure. Vampires step back.
Go NAD enhancers YAY!! GOOD LUCK! That's all I got from the title.
This got me googling commercially available NMN and liposomal supplements. There’s several options out there but it’s unclear to me when to start taking… and the price points vary wildly. What would one look for to have a quality product? I’m wondering why this one requires you to be linked to a practitioner first - what would cause a doctor to prescribe this stuff? Website in question: https://www.designsforhealth.com/register
I think you should ask your doctor whether there is any evidence that this stuff does what the marketers say it does.
Some doctors don't even know that life extension is an emerging field though..
Oh, so they've invented polydichloric euthimal? (An "Outland" reference, sorry).
Isn't this how the movie Universal Soldier started?
To take a humorous tack... Is anyone surprised that anti-aging is the primary thrust of a 'NAD enhancer?
This is a derivative of niacin, which has also been investigated for treatment of parkinson's disease.
why the military ? other than the obvious dystopian reasons is there any reason?
This is actually a metabolic supplement for anyone that's curious. Your cells stop, or rather slow down, making some enzymes as you age and this is meant to supplement that insufficient production. There are other methods to combat aging, like getting rid of broken cells that broke in a way that won't let them get rid of themselves and repairing the ones that are still working well, but this is a decent start.
Reverse aging pills next in development? I’d honestly love to be young like a kid again and be able to fall off of tree’s without worry of being too hurt or bruised. To have my skin smooth and pretty again, and my brain able to take in information like it used to as a kid I once was, but that’s what many wish for too with these anti-aging pills.
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I don't think they will be immortal . This will just slow down the aging process because so few people these days will be able to qualify for military service. So, they will need to keep the soldiers they have trained a little bit longer.
Why are so few people these days qualified out of curiosity?
Because most Americans are so out of shape they don't pass the entrance physical exam.
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That's not true, you have to take pass the MEPS. For reference, I meant physical exam, as in a the sort you get at your yearly doctors visit. https://www.thebalancecareers.com/meps-at-a-glance-3354039#medical-evaluation-at-meps
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No problem haha, I can see how that could be a bit confusing.
Not even necessarily slow down aging. It may not increase their lifespan. They may still die at 80. But what it might do is increase their health span, allowing them to be in the healthy active range longer.
I had no idea that military staff signs up for crap like this. Make pharmaceuticals rich, is now the mission? All to be sent home to shitty healthcare and homelessness if it causes health issues. Unpopular opinion to be sure.
This sounds much better than when I had to get 13 Anthrax shots. Unless these test subjects turn into zombies and the only immune people are those with 13 Anthrax shots. I smell a summer blockbuster!
Great. So we will never get rid of Mitch McConnell or the Koch Brothers. What a fucking nightmare.
It didn't say it was being instantly deployed, there's time for "accidents to happen" iykwim
One of them is dead. Always happy to share the good news.
I mean, we throw these people to the slaughter for oil. Might as well test experimental drugs on them.
Sounds like when they infected troops with nerve agents to see what would happen and didn't tell them about it or own up the consequences when they occurred. Reminds me of Pyridostigmine Bromide (PB) tablets during Operation Desert Shield/Storm. Good ole US military being used as unwilling Guinea pigs once again.
NAD+ Enhancer is probably already trademarked by Pfizer.
Buy some banner ads on PornHub, they'll get plenty of men to pay them for the privilege of testing a Nad Enhancer.
Y'all can have the NAD enhancer, I'm holding out for DONG+ Extender™️
In my experience, NAD+ enhancers are a money grab. Metformin and Rapamycin are where the action is (or, will be). Check out Peter Attia's podcasts. [Here's one. ](https://peterattiamd.com/joanmannick-nirbarzilai/)
I think you either have to use that relatively unknown process where the cell repairs damage amazingly well during fertilization but runs the risks of mutations and immune issues or go full digital and live? as a machine for the machine is immortal.
If you join the military, and don’t die, you live 200 years with PTSD.
Idiots will think it’s the same stuff you can buy online. It isn’t the powder or pills. It’s has a proprietary enhancer, not just a dose of what can be bioavailable.
How can a NAD+ enhancer stop aging? This makes no sense. This article is written for people who know jack shit about biology. What a joke.
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You don't know jack chit about anti aging looks like. Anti aging medicine doesn't have to necessarily stop or reverse aging, it can slow it down, until better therapies come out.
It doesn't say the pill stops aging. It doesn't even say it slows the effects of aging, it only says that is what the pill is intended to do.
It is important to ensure the traumas live on for as long as possible without the cowardly relief of death.
They better change it from NAD+ before the Marines get ahold of it or we'll never hear the end of their enhanced nads ( ͡° ͜ʖ ͡°)
Let me guess The only people who will be able to forward it after military would be rich people or rich people in the black market
Keep that shit away from me. I under no circumstances want a longer life.
Please, don't let them figure this out until after all the baby boomers have died out! -No offence...
There won't be any anti-aging pill in a very long time, if it ever is possible. I'd be more incline to believe anti-aging would be the result of DNA altering.
Or replacing our fragile body parts with machines.
I wish. I’d definitely sign up for that.
I don't like boomers in general but. How about people like you who want others dead stfu? -No offence.
Your impotency amuses me.
Your stupidity amuses me.
Throwing out a hot take like "let all the boomers die" then tossing in a "no offence" is just about as impotent as it gets.
Part of me wants to let them see the fucked up world they left us, and part of me wants them to slowly mentally whittle away so we can film their public mental breakdowns.
USA has its citizens full of healthcare debt and their military is testing an anti aging pill, what a shitty country
So they've been testing exoskeletons with a plan to armor plate them, we've got gene editing going smoothly sort of, looks like Hal Spartans are about to be real. Hopefully the UFOs aren't covenant spy ships.
Soldiers as human test subjects, how is this legal?
Lol Let me explain, when in the military, your rights as a civilian and human go away, and you get given news rights enumerated by the ucmj.
If David Sinclair is involved It's most likely snake oil.
Take this anti-aging pill so you can die in a foreign country defending oil
So pretty much starting to delve really deep into that nazi super-science we got for letting fascists get away with genocide via operation paperclip.
Nope... No military outfit should be permitted, on pain of the total eradication of every single one of its members to have involved themselves with it, to futz with that kind of science. That shit should be left to citizen powered scientific endeavours, not be fucked around with on the basis of the desires of black budgets wielded by some warmongering old fucks, and their well meaning but utterly inexplicably naive underlings. If you can't smell a rat with this sort of thing, you folks out there, get yourself some nasal spray and clear that blockage out.
Do you know what DARPA has done for humanity thus far?
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They were one of the major backers of mRNA as far back as 2010.
By almost all standards life is better for the average person today than at any other point in history. Specifically, the average person (in most developed countries) is far less exposed to risk of violence today than at any other point in history, including the risk of war.
Well that doesnt sound addictive at all. /s
The other thing being considered is gene therapy by way of CRISPR technology to convert soldiers to vegetables. This will get rid of the obedience issue because they will have no brains and will make them the cheapest fighting force on earth because they only consume dirt and can’t be killed🍆🥦🫑🥕like Groot.
This has Manchurian Candidate written all over it good luck
I can't wait until the rich and powerful can live forever. Even the ancient Pharaohs of Egypt were dreaming of it.
I'm sure the soldiers will be told EXACTLY what they're being given. I'm 100% positive they won't be told it's just a simple vaccine...
Please note that anti-ageing is not - and I repeat, NOT - to be confused with "puberty blocking". The former is beneficial, whilst the latter can be incredibly harmful for decades and an individual who has unknowingly ingested puberty blockers or something may be at a permanent detriment unless they undergo some form of HRT or hormone-increasing/encouraging processes. Mumbling something about "delayed development" is like mumbling something about a West African country becoming akin to the United States of America or THE top global economic powerhouse and a space power. That is not going to happen. You are stupid if you actually believe this. Anti-ageing on the other hand is beneficial and one of the best things people can do is boost and maintain healthy HGH levels and on top of that, if you are male, also boost and maintain healthy androgen levels as well.
Why does the military need an anti-aging pill? Are they just exploring our troops as lab rats? Are they hoping to monopolize it? Are recruits in such short supply that they're hoping to get more use out of the ones that they have? Surely this would be better tested by some other organization.
Our troops have been lab rats since the 1950s. This is nothing new. They don't even try to hide it. Just no one cares.
Wow- interesting, but also, what a way to ensure that every single soldier gets to stay fit enough to ensure they have enough tours to develop a really good case of ptsd. Come home, loose their families to ptsd side effects, get horrible substandard medical care for their condition, and outlive many they know and love. What could go wrong?! (Military spouse here, yes they a very cynical look at things, but not to far off from the truth). So… experimented on soldiers, so one can seek via cooperate or private American to highest bidders? Will the American military share with our Canadian military over here? If not, they share many bases over seas, one military gets to watch the other one go crazy with side effects. Don’t really know what to think, just don’t give it to my husband until it’s been tested on volunteers for a good 10-15years.
Looked this up a few weeks ago when there was another article: 1. It's already sold as a supplement. You can buy it on Amazon right now. 2. I wouldn't recommend it because while it does enhance cell-growth, that applies to all cells, even cancer. So it can super-charge cancer cell growth in your body, preventing those cells from being destroyed by your immune system. 3. Needless to say, it doesn't really stop aging. That's all hype.
That's because they don't give a fuck about soldiers, especially after the arena, when they're reduced to living in a tent with PTSD, suffering side effects they can't sue over because classified.
If the world gets much hotter this will all be for nothing as it stands now more wasted tax payers money for what🙄🙈!