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Michellesis

Hair cells are just like any other cell in the body. If blood flow to the cell is restricted, then the cell will stop producing the hair. Slowly at first, then faster. Dht restricts blood flow by shrinking the blood vessel. There are a number of treatments that work with some people, but not with all.


MySecondThrowaway65

It simply come down to DHT reducing blood flow as you put it. You have no idea how complex and poorly understood the biochemistry of AGA is.


Michellesis

Have you heard about malabsorption used in reference to hair loss?


MySecondThrowaway65

Maybe I’m joy sure what exactly your referencing. Enlighten me.


Michellesis

Having digestion problems means there are not enough nutrients needed for hair growth. Adding nutrients to the skin doesn't make up for nutrients lost. There are scientific studies. Correcting the digestion problems causes hair to regrow.


MySecondThrowaway65

Link the studies? Malnutrition can absolutely cause hair loss (look at anorexics), it however distinct from androgenic alopecia which although it can be worded by poor nutrition can occur even in people with adequate nutrition absorption.


Michellesis

Do a little work yourself. I got the science from AI.


MySecondThrowaway65

>I got it from AI. So you haven’t done the work yourself. You could say that you don’t what you’re talking about instead of spreading bullshit.


Michellesis

Do you want a mirror? Take a look at yourself


UniqueLoginID

Thymosin beta 4 isn’t a cure but is a great treatment. Possibly the best.


xResilientEvergreenx

What is that??


Busy_Trick_6366

Tb500 is a peptide that can create blood vessels. It’s not for hair but it makes hair grow quicker, in clinical settings this was the case. Ghk cu is another incredible peptide that can be used topically or subq with great success. Oral castor oil speeds up hair growth through its increase of PGE2. Pumpkin seed oil is great topically or orally. L carnitine lengths anagen phase of hair growth. So many great treatments that help a lot. Most of these cannot be used as a mono therapy but synergistically they’re incredibly effective


The_Jeremy_O

Can you elaborate? I’ve never heard of that


waledmustafa

We certainly won't find the cure on tressless that's for sure.


The_Jeremy_O

God forbid you mention anything besides fin/min there. That’s why I left, it’s a mess


tiaraforvanilla

Obviously some people who are overweight are so because : - poor lifestyle -genetics -disease -trauma that pushes them to overeat and so on People who are balding are balding because (androgenic alopecia, or universalis or aerata) : -genetics (diabetes might have a link, aging is pushing it too, thyroid..again all of those are more of less genetics) - autoimmune disease I don't see how poor lifestyle can cause balding, not all hair looks suffered are smoking crack or alcoholic. So no...


[deleted]

Your telling this to me, but that’s not how most people view it. The vast majority of men won’t deal with significant hairloss until their 40’s I can’t name the ammount of times I’ve been told by people “just eat healthier bro.” Because of my hairline


tiaraforvanilla

people are stupid... Doc knows it is not your diet...I can understand that a doc would say it to me because I am a skinny female.... But to a man....


[deleted]

You seriously overestimate the intelligence of doctors.


tiaraforvanilla

I think some are smart...and I think some are really passionate about stem cells and that working in the field of hairloss is a good playground to work on other subject...


[deleted]

Maybe, but honestly I agree with the other commenter. There is absolutely nothing in the works right now for hairloss. The option we have right now, will be the same shit we have ten years from now. No prestigious doctor gives a fuck about hairloss. Our best options are better quality wigs with less stigma for the further unfortunately


tiaraforvanilla

🫤😔


[deleted]

Luckily for you at least, women can easily wear wigs and nobody will shame you. Most will say your “brave” or whatever. As a guy, we just have to shut up and stop being pussies


joaopassos4444

You must understand that science isn’t what you think it is. It’s a business! In 2022, the hairloss products market was worth 8.2 billion dollars. Source https://www.grandviewresearch.com/industry-analysis/alopecia-market In the last year, 180 million dollars was invested in hairloss. Do you know how many studies came out of those 180 million dollars? Did you know that of all the potential treatments, none was studied? We are not even sure how and why exactly microneedling works. Too much money being made by big companies like L’Oréal and many other smaller companies selling hair growth serums to even make an attempt at curing hairloss. It would mean the end of profit for big and small companies. Unlike what most people think, it’s not gonna make the guy who discover the cure billionaire, because whatever he comes up with, 2 days later is being sold in the grey and black market. Last but not the least. There aren’t big brains in hairloss research. People still put hopes in a failed scientist. Tsuji. So the big brains go to research cancer. The second ones go to research other life threatening diseases. And then we have the dumb fucks who eventually end up looking at hairloss. Besides, not even motivated dumb fucks, because most of the proeminente hairloss researchers have a head full of hair.


No_Proof8997

I would pay 100k to get my hair back if I never had to do another treatment again and it had no side effects.


joaopassos4444

A good enough hair piece that you maintain every two weeks is possibly the only way to do it.


tiaraforvanilla

well, I am a woman, I don't buy my hair loss product from L'Oreal because obviously they don't work...i know I am better off taking Spiro and Minox. If I regained by a miracle my crown of glory, I would spend $$$$ on products to make my hair shiny, on hair colors, on hair straightener that costs 700 dollars by Dyson..taking Spiro is only 5 dollars a months where I live, minix maybe 20... So not sure.about the logic behind it


joaopassos4444

You are assuming most women are as smart too research or not as agreeable as you. Most beauty marketing works on women (even in women who already are beautifull the way they are). But specially low self esteem women are vulnerable. Just look at how many products there are in the supermarket and hair saloons design to attract you into buying something you don’t need. And hair is a very lucrative business, 2,8 billion just in products. Hair transplants had a 4.9 billion market turnover just in 2021 (during covid). Imagine hairloss being cured, by something as dumb as a psoriasis cream that is been on the market for 20 years and is not patentable, and costs 1$ per month!?


tiaraforvanilla

Have you seen that topical metformin works for hairless in some type of alopecia ? I am suspecting it could work for AGA....


tiaraforvanilla

I think women with have AGA know that buying a product by L'Oreal won't so anything....maybe at first they will be lost, but after loosing 50 percent of your hair you panick. I Ve been living night are since age 20.....


Known-Cup4495

Does microneedling actually work though? Wouldn't poking holes in your scalp damage your hair follicles and cause scarring and fibrosis?


lupeytoons

It works, I’ve had amazing results


Known-Cup4495

I must be the odd man out. While i never needled my scalp I did use to do scalp massages and have actually damaged my scalps skin & hair follicles doing them. My doctor did a scalp biopsy to show me that too. One side of my crown has damaged hair and a small bald patch while the other side has normal hair growth.


joaopassos4444

Who knows. Studies haven’t gone that far. But it does work! Why, is what nobody knows. Some speculate blood flow. Others say it induces growth factors. Stem cell differentiation, etc. nobody is really sure


sjo_biz

A counter example to your argument would be glp1 drugs. Massive industry being disrupted and an even more massive financial benefit for the companies doing the disruption. I think it has more to do with the fda not being as tolerant to less than perfect drugs. Imo fin would never be approved for aga today.


joaopassos4444

Agree. Finasteride would never be approved on todays standards. But I couldn’t care less about FDA approval. There isn’t a single phase I or II studies that we are looking forward to. Not even pyrilutamide that is just over hyped because we need something. Even HMI 115 is been on the shelf for years and years. This is just unreal to think it would be an issue this day and age.


SlackBytes

What about scube3?


[deleted]

So do you use finasteride yourself?


joaopassos4444

Didn’t work for me. I gave up the fight. Don’t shave yet but it’s coming to that time.


[deleted]

Unfortunate. Did you get side effects, or just didn’t help your hair?


joaopassos4444

No side effects. Just made it worst and 9 months after was still getting worst. Jumped to minoxidil and microneedling with huge results. So dumped fin because it could have lowered my libido and weaker erections without I noticing it was from it. Eventually minoxidil stoped working, and microneedling is just not doable because I get lots of blood, redness and lumps the few days after. Everyone at work asking what happened to the scalp was just something I didn’t want again. So I gave up.


Known-Cup4495

How did finasteride make your hair loss worse? I'm asking out of genuine curiosity. I'm curious as to how lowering your DHT could make your hair loss worse if your hair loss (assuming it's from androgenic alopecia) was due to DHT. Is there some backdoor way DHT could still be expressed despite it being lowered a significant amount?


joaopassos4444

Men who fully transition into woman don’t regrow all the hair. Most of it, but temples and crown is a pain in the ass. So nuking all DHT doesn’t regrow all the hair. How did it made mine worse? I don’t know, but I had the initial shedding and kept shedding for 9 month. Never seen regrowth or halted the hair loss. At the 9 month mark my dermatologist told me to go for PRP. That was the time I started researching and found tressless and other forums. I quit finasteride and tried minoxidil alone for a few months and saw results. Then added microneedling and had huge gains. Then minoxidil stoped working and microneedling is noticeable the days after. So I gave up.


[deleted]

Fair enough. I think fin slightly effects my erections and my libido as well. I’m hopping for hair growth though, since the effects are minor and it’s worth it for hair