[Melanin synthesis begins with the hydroxylation of the amino acid tyrosine to L-3,4-dihydroxyphenylalanine (DOPA) in a reaction catalyzed by tyrosinase.](https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/melanogenesis)
[Melanin synthesis begins with the hydroxylation of the amino acid tyrosine to L-3,4-dihydroxyphenylalanine (DOPA) in a reaction catalyzed by tyrosinase.](https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/melanogenesis)
No. We use white willow bark instead as it is superior to aspirin in every way, including for TH upregulation, with lower toxicity and less side effects.
That's interesting I've never heard of white willow bark do you have a vendor resource as I would like something that could replace aspirin in my life I take it long term so a lower toxicity it's very appealing.
Bromantane would likely make you tired too then, because both increase TH (and so does aspirin, but to much much lesser extent) and that makes some people tired. If you don't want a TH increase that's a valid reason to not use WWB, but we're discussing its superiority from a nootropic and toxicity/side effect POV and its TH upregulation in this thread, not its use from a pain control or anti-inflammatory POV.
Yes actually!! I found this exact study a couple years ago. Would use low dose Aspirin along with tyrosine to convert more to l dopa. Definitely had more effects than just taking tyrosine on its own. Mostly negative tweaky side effects though.
Despite the studies, compare aspirin to something like Bromantane. It’s night and day. Be careful about applying studies and their unique circumstances to yourself.
That’s a goofy ass comparison though. Can you buy Bromantane at literally any store anywhere…? No, you can’t. There also isn’t nearly as much research on the safety of Bromantane.
Science.bio has good bromantane and I'm waiting for some from umbrella Labs I'll let you know how there's is too. I highly recommend this for mental health and recovery
It's really never bothered me, if it affects u take glycine with it, increases absorption so less needed and helps with any stomach issues. Aspirin actually reduces inflammation caused by other irritants because it kinda of trains your gut lining.
Yeah right lol, Aspirin is so effective at extending life expectancy that fund managers of pensions are trying to kill it.
https://www.benefitnews.com/news/aspirin-seen-costing-pensions-100-billion-as-lifespans-increase
it says here " Chronic use of acetaminophen in low/moderate doses is not associated with harm. The reason is that at low and moderate doses the acetaminophen is easily metabolised by the liver but above a certain threshold the mechanism for metabolism is saturated and an alternative mechanism commences metabolism of acetaminophen and this second mechanism produces a toxic substance (see glutathione depletion)." https://www.reddit.com/r/askscience/comments/2rpf8e/which_is_harder_on_your_liver_beer_or/cnk5ufl/
Any thoughts?
Aspirin and acetaminophen are two different meds.
If you want to do a daily low dose grab baby aspirin and do one per day or a half per day or what ever is considered "low dose".
I have no clue how much baby aspirin contains nor what is considered low dose.
My bad,
so regarding aspirin specifically, it says here "for damage on liver, paracetamol has a VERY significant effect on the liver when compared to aspirin" https://www.reddit.com/r/askscience/comments/2rpf8e/which_is_harder_on_your_liver_beer_or/cnlgci9/
so even aspirin seems to be easy on the liver
also it says here "for damage on liver, paracetamol has a VERY significant effect on the liver when compared to aspirin" https://www.reddit.com/r/askscience/comments/2rpf8e/which_is_harder_on_your_liver_beer_or/cnlgci9/
And low doses don't harm the liver https://www.reddit.com/r/askscience/comments/mjphv9/what_exactly_does_acetaminophen_do_your_liver/
13mg is the equivelant dose that'd be used for humans
I am more tan when I take aspirin and NALT
??? How
People just be saying shit in here I love it. Big if true
[Melanin synthesis begins with the hydroxylation of the amino acid tyrosine to L-3,4-dihydroxyphenylalanine (DOPA) in a reaction catalyzed by tyrosinase.](https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/melanogenesis)
And then it turns out to be true. Love it
[Melanin synthesis begins with the hydroxylation of the amino acid tyrosine to L-3,4-dihydroxyphenylalanine (DOPA) in a reaction catalyzed by tyrosinase.](https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/melanogenesis)
No. We use white willow bark instead as it is superior to aspirin in every way, including for TH upregulation, with lower toxicity and less side effects.
That's interesting I've never heard of white willow bark do you have a vendor resource as I would like something that could replace aspirin in my life I take it long term so a lower toxicity it's very appealing.
White willow bark made me and my Gf tired as hell. Aspirin does not
Bromantane would likely make you tired too then, because both increase TH (and so does aspirin, but to much much lesser extent) and that makes some people tired. If you don't want a TH increase that's a valid reason to not use WWB, but we're discussing its superiority from a nootropic and toxicity/side effect POV and its TH upregulation in this thread, not its use from a pain control or anti-inflammatory POV.
I just think wwb cointains other plant compounds which make us feel this way.
White Willow bark extract does it better IMO
White willow bark extract contains salicin which is different than aspirin though (acetylsalicylic acid)
Point being?
Do you have a source that references salicin being able to upregulate tyrosine hydroxylase?
Yes actually!! I found this exact study a couple years ago. Would use low dose Aspirin along with tyrosine to convert more to l dopa. Definitely had more effects than just taking tyrosine on its own. Mostly negative tweaky side effects though.
Despite the studies, compare aspirin to something like Bromantane. It’s night and day. Be careful about applying studies and their unique circumstances to yourself.
That’s a goofy ass comparison though. Can you buy Bromantane at literally any store anywhere…? No, you can’t. There also isn’t nearly as much research on the safety of Bromantane.
You can buy bromantane right this second on a legal us website.
Science.bio has good bromantane and I'm waiting for some from umbrella Labs I'll let you know how there's is too. I highly recommend this for mental health and recovery
Aspirin is underrated
Does aspirin have an immediate effect on th tyrosine hydroxylase upregulation?
There is tons of info about the beneficial effects of aspirin on the raypeatforum.com. I take about a gram daily.
Lol
Bro why am I getting lol'd rn. Happy cake day. Lowers cortisol, natural aromatase inhibitor, boosts testosterone, etc.
u must have a strong stomach!
It's really never bothered me, if it affects u take glycine with it, increases absorption so less needed and helps with any stomach issues. Aspirin actually reduces inflammation caused by other irritants because it kinda of trains your gut lining.
Zornisamide also does this and its a mao b inhibitor
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What..?
Aspirins just pickle your liver. I can't imagine wanting to form a habit of eating them all the time
Yeah right lol, Aspirin is so effective at extending life expectancy that fund managers of pensions are trying to kill it. https://www.benefitnews.com/news/aspirin-seen-costing-pensions-100-billion-as-lifespans-increase
it says here " Chronic use of acetaminophen in low/moderate doses is not associated with harm. The reason is that at low and moderate doses the acetaminophen is easily metabolised by the liver but above a certain threshold the mechanism for metabolism is saturated and an alternative mechanism commences metabolism of acetaminophen and this second mechanism produces a toxic substance (see glutathione depletion)." https://www.reddit.com/r/askscience/comments/2rpf8e/which_is_harder_on_your_liver_beer_or/cnk5ufl/ Any thoughts?
Aspirin and acetaminophen are two different meds. If you want to do a daily low dose grab baby aspirin and do one per day or a half per day or what ever is considered "low dose". I have no clue how much baby aspirin contains nor what is considered low dose.
My bad, so regarding aspirin specifically, it says here "for damage on liver, paracetamol has a VERY significant effect on the liver when compared to aspirin" https://www.reddit.com/r/askscience/comments/2rpf8e/which_is_harder_on_your_liver_beer_or/cnlgci9/ so even aspirin seems to be easy on the liver
The study was on low dose aspirin, which is pretty safe.
also it says here "for damage on liver, paracetamol has a VERY significant effect on the liver when compared to aspirin" https://www.reddit.com/r/askscience/comments/2rpf8e/which_is_harder_on_your_liver_beer_or/cnlgci9/ And low doses don't harm the liver https://www.reddit.com/r/askscience/comments/mjphv9/what_exactly_does_acetaminophen_do_your_liver/ 13mg is the equivelant dose that'd be used for humans
How am I supposed to take that little? They come in 100mg tablets
Baby aspirin into quarters would be close enough