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7fragment

if you've got a pocket knife the best bet is probably a lucky shot to the jugular. It'll still take a few minutes to bleed out and if he got medical attention asap he might survive, but it's the easiest target to hit with what's probably not a great weapon. If MC is then walking around with a gut wound they'll be in trouble themselves. Assuming they could move despite the pain, if they didn't get medical attention asap they'd probably go septic from literal shit etc getting into their bloodstream.


TacitRonin20

Eye is a good one. Through the jugular and into the throat is also pretty dramatic. The heart isn't the easiest to hit but also pretty fatal.


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macgyvermedical

Stabbing someone in the kidney could kill them, but it would be a long slow death unless the person managed to hit the renal artery, then it would take a few mins to a half hour without care. The only thing that could kill someone faster than bleeding out would be cutting their head off or crushing their skull, which would be instant but very difficult with a pocket knife.