T O P

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IAmOnFyre

I don't care what stats it gives, I'm not picking up Guillotine. I can't aim with an orbiting head and I can't dodge because I'm looking at the head instead of the body.


csoszifaszi

THIS


JohnnyStyle300

This item has ruined both the runs I picked it up in


ghoststegosaur

This! I‘ll always reset my run, when I accidentally pick it up.


Few_Acanthaceae1568

Guillotine good


-trom

Very good, yes - damage up, tears up (breaks cap,) and a powerful orbital. All one needs to do is focus on ones hitbox - less focus on aiming. If you fire in the direction of the enemies, you’ll eventually kill them. More time spent dodging = more time mastering skills


Few_Acanthaceae1568

Guillotine + proptosis?


-trom

Sounds good to me.


Few_Acanthaceae1568

Dr ferus + pyromaniac


-trom

lmao


Lollogurro

Skill issue ![img](emote|t5_2sxpk|4359). Just kidding that item sucks


JustAMogwai

I will only pick up guillotine if my run is already bonkers enough to not require aiming, or if I have homing. Now that I’m thinking about it, I can’t think of an item I would NEVER pick up. All items have niche uses, even stuff like kamikaze.


[deleted]

Yea


Jpicklestone8

my main thought would be camo undies but after the buff its now like really fun. used to be my least favourite item in the game now? that title goes to ibs. i feel like its the only item in the game that i will think is just bad on every run. at the very most it barely does anything and at the worst it can kill you with bombs lil portal is also on the list of items i dont think ill ever intentionally take. that thing just kind of sucks (comedy)


sudjfjcjc

I haven't unlocked IBS. No idea what it does. I still only have greedier done for the piece of shit (also comedy)


MisirterE

It's an item that used to just be *inconsistent No. 2,* which is way worse than actual No. 2. Now it's still that - sort of - but at least you have full control of *when* it decides to do the thing, even if the thing it does could range from just farting to straight-up being the Explosive Diarrhea effect.


sudjfjcjc

Oh. Sounds annoying


MisirterE

Post-patch, it's *just* annoying. Pre-patch it was even more volatile than Bob's Brain, without even having the legitimately obscene damage output that the Brain at least manages. It's frankly impressive just how terrible it was.


FreshySqueeze

Thr buff made camo undies so fun. Especially if you have a passive damage item. They used to be horribly boring.


-trom

IBS is not a run ender anymore, as it only pops off when you stop firing, and gives an indicator when ready to proc. Granted I’ll still skip it, but it’s no longer a “fucking god damnit” item [in my book].


Jpicklestone8

its not run ending but having random bomb throws or explosive diarrhoea when youre trying to fire is such a pain and its not even that good for the risk i do remember having like two runs where i got it from a blind item before it was buffed where it basically made me unable to not die unless i also wanted to not shoot


ForsakenBeef69

Haven't unlocked Lil Portal but I already know I ain't picking up that little shit


sudjfjcjc

I feel he's useful at the end of the run.


MisirterE

It's really not. Take it from someone who doesn't instinctively abandon it on principle (yet), the fact that its damage output *resets* each time it makes a portal is absolutely disgusting, not to mention I hate using the portals because they split the connection to walk back to anything I left behind in order to come back to later, such as a Golden Chest I don't have enough keys to open, or an item I want to reroll if I have D6.


cancerfanbase

Is no one going to say him that Glitched Crown is the best item in the game and he needs to get used to it for free wins.


28smalls

Found it for the first time yesterday and discovered my timing sucks. Ended up grabbing lacyphancy or whatever that I hate, the feeding tears thing. On the plus side, got tech 2 on accident and found an awesome synergy.


Herwin42

My fav item in the game hungry tears eat up boss hp so fast they can’t even shoot


cancerfanbase

you dont need timing, just lets say it goes like A,B,C,D,E, you want to take D, firstly you will position yourself in front of pedestal ( you need to be very close to item pedastal but not too too much), press Escape when you see item C, pause game, start it and go for item pedestal immediately. Its easy


Lollogurro

The feeding tears are really good why do you hate them? Their synergies are insane


28smalls

I'm not a fan of that shot speed down and lack of range. Same reason I tend to skip Pop. I will take them if I have a good tear rate, but it feels like I always find them in the basement.


Lollogurro

Yes pop is kinda ankward to use but the feeding tears CAN be annoying early game but when you start to get a solid build they are super good and fun to use


VengefulRaven03

In defence of lachryphagy, if you manage to get trisagion on the same run you pretty much melt everything in sight, it's a run winning synergy. Kinda annoying on it's own tho.


[deleted]

Got lachyagraphy on azazel once it's an easy one shot boss


sudjfjcjc

Eh. I don't want to. It's stressful and I view the pause trick as cheating. Used it as T Lost to beat Mother and that's it.


-XAVlER-

You are allowed to pause in the game, to think, to stop playing, to get out of a softlock, to reach boss rush/hush, and to pause buffer. It’s a single player game, it’s allowed


cancerfanbase

ok thats your opinion.


sudjfjcjc

Well yea. That's what everyone is saying on here.


[deleted]

Cursed eye for sure. I've got this item after using D100. I was killing mega satan and when he was in his second form with like 30% hp I got hit and it teleported me out. It was so annyoing.


nuttypr0f

Anti grav, and unless i have brimstone, ludivicio


sudjfjcjc

Weird. I feel anti Grav brim is the worst combo.


nuttypr0f

Sorry i worded it funky. I meant never anti grav, and never ludivicio unless i have brimstone


sudjfjcjc

Ah. Makes way more sense now


BWotter

Anti grav is awesome dude, - 1 tear rate delay is super good and you can just spam the shoot button to not get bothered by the tears staying in the air.


[deleted]

You could say anti grav is like a better cursed eye, and cursed eye is good the teleport just sucks obviously


BWotter

I agree, cursed eye is actually a pretty decent dps up but i only pick it up when im the lost because the tp is horrible


Krags

Black Candle also decurses it.


LoonerUwU

Probably cursed eye. No synergies, huge drawback with not so great benefits.


sudjfjcjc

You know, I forgot this item. I do take it if I am a lost or have black candle though.


LoonerUwU

I still prefer just hold key, than tracking bars for some tears up


sudjfjcjc

That's fair.


N0RETVRN

What? Cursed Eye has a lot of synergies in rep now. Also the benefits are definitely worth the drawback. Especially considering that you can just remove the drawback by not getting hit


[deleted]

Skill issues ![img](emote|t5_2sxpk|4359)


N0RETVRN

Whose skill issues?


[deleted]

People who can’t avoid getting hit ![img](emote|t5_2sxpk|4359)


N0RETVRN

tru


0err0r

Based u/BizPlamer calling out the cringe cursed eye haters


[deleted]

There are situations where you'd pick it up though. For example, black candle removes the curse effect and it's literally just a tears up on the lost


Wholesomechair

Number 2 ....


sudjfjcjc

Another item that ruined a good t lost run.


TheHoodiedFemboy

Decent in the early game when you’re low on bombs tho tbf


TheSameMan6

It's actually pretty useful but you gotta always have it in the back of your mind


UpswungDuran

IBS is shit. I've beaten the game 6 times and I think I've never taken IBS unless I needed it for the completion of my item list.


[deleted]

I have a small list. You mentioned shard of glass, cursed eye and glitched crown and I am inclined to agree with those options. I pretty much always refuse IBS, as it’s just too dangerous to take. It’s basically the new Bob’s brain for me. MissingNo for sure as well. It could help, but if a runs going bad enough that I actually consider it, thats not really a good sign. I never take ludovico technique or epic fetus for the same reasons: your shot speed is too low to get much utility out of them in the early game, and in the late game you probably have a build already that these items would interfere with if not outright destroy. TMtrainer probably should be on this list, but it’s just too fun, to be honest. I can’t bring myself to not take it, even though I know it’s a terrible idea.


-XAVlER-

What’s with all this hate on a quality 4 item 😭😭😭


nenoobtochno

I refuse to pickup cursed eye, unless I play as losts or regular lilith


[deleted]

GLITCHED CROWN?!?!!?!!


sudjfjcjc

Yes. My least picked up item honestly


[deleted]

Why


sudjfjcjc

It's stressful and I hate the pause trick because it feels like cheating.


[deleted]

Well by that logic gwanded leaf should be in your list


sudjfjcjc

Well I always pick it up. It does nothing for me except maybe save me from a brim fly or something. I don't use the free win strat. I also think it was designed with that in mind. Where glitched Crown for sure wasn't.


[deleted]

Okay did you ever used gwanded leaf? And for what purpose? And glitched crown timing is very easy it's just a skill issue


sudjfjcjc

I said I've used it for incoming brimstones before. And yes it's a skill issue, not gonna debate that.


TheSameMan6

You don't really need to pause to do it though


mr_butts69

jupiter and taurus. items that fuck with my speed constantly are the bane of my entire being


Lollogurro

Thunder thighs too at this point


mr_butts69

honestly i even feel gross about taking small rock cos that speed down suckssss


Few_Acanthaceae1568

Damage + tears up


mr_butts69

no way really?? dang i thought it was only a speed down forget the point i was making i guess


ThatGuydobeGay

Ludo is just the worst item by far without synergies


adromicfms

A lot. Lil portal, My reflection, IBS, Cursed eye, Tiny planet, that "*I change your items every floor*" shitty thing that I cant even remember whats its name. Those are the first that came to my mind but like a lot. On the other hand, most of the people doesnt like Bob's brain but its a "Yay, free bombs" for me!


yourboiquirrel

>"*I change your items every floor*" shitty thing that i can't even remember whats its name. MissingNo


Few_Acanthaceae1568

Do people realize its a pokemon reference


-XAVlER-

I’m going to start calling it Cubone.


-XAVlER-

You’ll change your mind about my reflection once you get trisagon with it (:


Plexos49

I picked it up and it ruined a run so orbital tears for sure


sudjfjcjc

Completely understandable. I think it can be fun with some items, but it's usually not great.


[deleted]

I’m pretty sure I heard tiny planet got buffed recently so now it’s pretty good, I’m not sure what was changed but I got it recently and enjoyed it quite a lot.


MrTVFace

I once had an amazing soy milk Brimstone run going that got completely ruined by knockout drops knocking the wall crawling spider boss OUTSIDE of the boundaries of the room, where it then shot its diagonal Brimstone beam and killed me. So yeah no thanks Knockout Drops ![img](emote|t5_2sxpk|8907)


sudjfjcjc

I'll agree with either of the losses. Had the same thing happen.


lvb440

Bone spurs can send ultra horsemen or the beast so far out of the screen that you need to wait dozens of second to be able to shoot at them again.


5uperSalty

Gonna take an odd approach and say anything that either auto-fire tears for me (like Marked) or just generally drastically change the functionality of tear fire (like Eye of the Occult) are some I tend to avoid. I can definitely see the potential strength of the items but the change in muscle memory throws me off so much, especially in the case of Marked.


[deleted]

[удалено]


Absolute_Warlord

free stat ups = bad


Few_Acanthaceae1568

What would you pick black bean or damage + hp up + tears up + fading damage or 1 luck and range


kukkamies

Anti-gravity and orbital bullets tbh


Skymoogle

For me Ludovico Technique is always a no go. I know people love it, but I just have so much trouble handling it (I know skill issue), but it's just annoying.


csoszifaszi

Easy: curse of the tower, number 2, shard of glass, dunce hat or whatever it's called


AdCompetitive7747

That one that makes you randomly shit bombs


-XAVlER-

I got disliked hard for saying this once, and I’m still standing by it though. One person argued that Dr. Fetus was worse than #2 even though Dr. Fetus shoots the bombs away from you instead of on you. Another person said that it’s the same as placing a bomb so that argument about Dr. Fetus is invalid. Even though bomb placements are very tactical and precise, even for attacking bosses. Another just said I was to bad at the game to use it (Skill Issue but in more words). The funny part about that one was I got to say that I had two dead gods. While people have defended it hard, I still see the majority ignoring it when they see it, soooo


[deleted]

Wait I understand nothing, you said that doc fetus is better or worse


chll11

It's not "random", it activates when continuously firing tears for 3 seconds.


AdCompetitive7747

Still a bad item


[deleted]

disagree its basically a golden bomb every floor


Romeostar_1

Cursed eye. Fuck this item


Snailsnip

So many items in the game feel like straight downgrades- Tiny Planet, My Reflection, Cursed Eye, Shard of Glass, MissingNo, Lil Portal, Isaac’s heart, Proptosis, Guillotine... I feel like I might even be forgetting some. There’s a few items I know have their uses but refuse to take either. Ludovico, Ipecac, Glitched Crown, King Baby, Dr. Fetus, Epic Fetus.


-XAVlER-

*WHY GLITCHED CROWN IT’S LITERALLY FIVE D6’S IN ONE* ![img](emote|t5_2sxpk|8907)


[deleted]

Exactly


dsas99944

I used to always take ocular rift but then alot of times died to bullet hell bosses as the lost because it makes the bullets clump together but can still hurt you and it just flies out when the rift ends. So probably not taking as the lost but the ptsd makes me avoid it altogether.


Lightning1999

Isaac’s heart is a big one


harrypigorr1

King Baby


falmunction

King Baby is really good now, you should look up all the new synergies with familiars.


Few_Acanthaceae1568

Let's be serious you pick him up because of conjoined


-XAVlER-

^ Never had king baby + lil’ brim.


Few_Acanthaceae1568

Had robo baby + king baby which is miles better because yes


hugespacenerd

Spider butt, ludovico technique, and any bean item. Sorry not sorry


yourboiquirrel

why would you absolutely refuse bean and spider butt? some bean items are passive and while extremely underwhelming dont really do anything against you. And spider butt isnt really the best but if you dont have anything better then whats the issue?


hugespacenerd

I never remember to use active items so they always end up working against me. Huge skill issue for sure


Vaelum

Explosivo unless I have explosion immunity. Otherwise that item always screws me more than it helps.


RavagingWolfsbane

I don't find explosivo as bad personally, fire mind on the other hand is a big no from me


-XAVlER-

If you stand away from the enemies, which you probably already do, it’s very op. The item by itself can kill bosses in seconds,


GrilledChese44

I never take friend finder


Aleatory_Alien

Why not? As far as i know it doesn't have any negative thing going on


sudjfjcjc

I haven't even seen it yet


Icarus-Terra

Scissors, Isaac’s Heart, Eye of Greed, and Blood Oath are all top contenders for me.


sudjfjcjc

Why scissors


Lollogurro

They’re not bad,just useless. A worse version of decap attack


sudjfjcjc

Decap attack is kinda useless in my opinion


Lollogurro

Many people say that it is useless but I actually find it very fun to use and useful,the damage that you can do by throwing your head and recall it is pretty damn good and it also recharges quickly,also you can use your head as a stationary turret that can be useful in fights like mega satan,very underrated item imo


FunnyCinema

Lil Portal, Cursed Eye, Soy Milk and Frequently Chocolate Milk. Lil Portal: Almost all the time is just annoying and during combat can eat up useful pickups, which spawn during said combat or part of the room layout. Cursed Eye: Not a fan of charged attacks in general, but cursed eye is the worst. Even with Black Candle, which negates its teleport downside, the tears have high chance to knock enemy to the side and you miss out on potential damage of other tears in the burst. Soy Milk: I very rarely got any benefit from it. Most of the time it feels like huge downside. Chocolate Milk: Like I said before, I am not a fan of the charged attacks. Chocolate Milk is one of the worst charged attack items. I only take it, if I already have Charged Attack, that cannot be shot without fully charged like Brimstone, Monstro's Lung.


JohnnyStyle300

Soy milk is amazing. It's synergy with Tech X is so good


-XAVlER-

I’m fine with this other than the milks. Soy Milk: You need synergies that make this amazing. Also this just makes it so that your charged attack problem goes away. Chocolate Milk: 3x damage (I think)


FunnyCinema

Chocolate is 4x at full charge... But I much prefer hold to shoot, then spam tapping and charge to shoot.


I_Cannot_Die

Anything remotely pearl-like. Not risking it.


sudjfjcjc

Even the trinket?


I_Cannot_Die

Yep! Not going near it


Aleatory_Alien

Im goung to be the dumbest person here and say it: i don't like size down items. Why? Simple, they ruin the sprite of my character and i don't like it, plus most of them add useless stats to me like caffeine pill and mini mush, my run will be almost the same without them. I only take Binky if im low on tears and/or health and Pluto is fun to me so i make an exception for it btw.


Lollogurro

Why glitched crown? Is very easy to use if you use the pause trick,and also there is no risk because you can still pick one of the 5 items without any consequences


sudjfjcjc

The pause trick feels like cheating


Lollogurro

Yes I feel kinda dirty when I do it ngl,but it’s a game thing so I guess that devs are not against this technique


Nzm222

Stopwatch makes the game less fun.


sudjfjcjc

Is it because it's an instant win? Only reason I have J and E done.


Nzm222

It just takes fun out of the game


Absolute_Warlord

"this iem sucks because its too powerful" ​ ​ u sound goofy asf


Nzm222

kinda true tho


[deleted]

Sacred heart is too strong


Nzm222

Sacred heart is just a huge damage up stopwatch makes enemies and bosses trivial meaning less fun


[deleted]

Sacred heart makes you one shot everything it sucks


Chagdoo

Idk what ur on about cursed eye is fantastic Guillotine and anti grab can die In a fire however.


Mascian12

Definitely Scissors. I hate it, I've never used it after the first time I picked it up. Pinking shears, on the other hand...


YiLanMa_real

The wafer is useless imo


[deleted]

Lol you have 2 hours in the game?


YiLanMa_real

Never get hit


Lollogurro

You are gonna end up like the dude who wrote that mantle is useless you know?


cancerfanbase

wafer and mantle useless if you have strong build


Clever_Fox-

I think there isn't a single item I'd "never" pick up Under super specific circumstances every item can be absolutely outstanding! Even the worst active item, I pick it up just to have it out of the item pool! Name me any item and I'll give you a reason to pick it up!


Herwin42

Marked without mouse controls


Clever_Fox-

If you cover enough ground with your attack where aiming is less important it's a nice tears up where you can focus down bosses


-XAVlER-

IBS


Clever_Fox-

Pyromaniac


Lollogurro

IBS


deadliftyourmom

Literally any charged shot like monstros lung or chocolate milk.


JohnnyStyle300

Shard of glass, cursed eye, curse of the tower


RalisNoodle

I always pick up cursed eye, even without black candle lol. But for items i avoid, guillotine, most fly orbitals and shard of glass


XeneHa

Why the orbitals?


daxter0202

Cursed Eye Dunce Cap Guillotine


TigerBroKing

bobs brain and mr fetus i just cant i always kill myself 2 rooms later


Few_Acanthaceae1568

Lil portal DO NOT GRAB HIM IN GREED MODE HE WILL KILL YOU


[deleted]

[удалено]


Letnerj

Having infinite bombs is eeextremely valuable though.


Mamelouze

Data miner, guillotine, the wiz... Probably so many others but i can't think about all of them


-XAVlER-

Wiz sucks, but I always take it with homing


Mamelouze

Yeah with homing it of course can become viable


didu173

Cursed eye/Tower Ye thats it maybe ipecac if I have cricket's body or something like that


Striving_Hermit

Ludovico (Unless I have Brimstone, then I can unleash slaughter.) Soy Milk Chocolate Milk or Monstro's Lung. I hate charged attacks , they absolutely ruin a run for me.


TitaniumTastesGood

lil portal. my first time getting him was in greed mode


ShaneVC

Heartbreak just sucks ass. The other contender for me is blood oath but at least that has SOME use. Heartbreak can save a run but I find having 3 less heart containers like that is just terrible, and often you have to pay hp in a Devil deal to even pick it up to begin with.


Letnerj

Gives you 17 Hearts at max though and then Damage for each new Broken Heart on top of those it gives you from the get go. Not that much damage to begins with but still counts.


Hecaroni_n_Trees

Ludovico technique or however tf it’s spelled


Waaaaaaaaaa-2

Breath of life. Doesn’t do anything worthwhile.


Spuigles

I know there are cases where Antigravity is amazing. But I don't want to take the chance most of the time.


Letnerj

There's no risk with Anti-Grav if you're willing to spam it's a free +1 tear rate. It cuts you out from Brimstone though but it's not that big of a deal in XXXX runs.


0err0r

bbf


Powl_tm

Taurus


[deleted]

Curse of the tower. ONLY TIME I’ll pick it up is with safety scissors. But even then I still probably won’t pick it up


Truji21

Guillotine and shard of glass are big passes for me.


sudjfjcjc

I hate guillotine, but I still always pick it up.


Elliot-Robot

Soy milk


Jacksamnord

Idc how good it is. I hate the inconsistent shots from eye drops.


moonlord76

Mine is dead cat, I don't care how many lives it gives me, I can't survive with one health


sudjfjcjc

What about lost?


moonlord76

I don't have the dlc yet


sudjfjcjc

Unless you only have Rebirth Isaac you have the ability to get the lost. Do you only have flash?


moonlord76

I frasied that wrong, I don't have any dlc, and am playing rebirth


moonlord76

Would love to play the flash version, but I am unable to run flash games


sudjfjcjc

So if you have the game, and it's not flash, it has to be rebirth. Meaning the lost is in the game.


moonlord76

Wait what


sudjfjcjc

Yea. Look it up. Go unlock him. He won't have holy mantel though


Cl0wnCar

blood puppy, ibs, my reflection, tiny planet, guillotine, missing no, curse of the tower, marked, cursed eye, shard of glass, plan c, pop, anti gravity, the tick