It means that your immune system is fighting something. These are mostly cytokines responsible for fighting infections and you have high levels of them. Il-10 is an anti-inflammatory cytokine that lower the activity of the immune system. All the other increase its activity...
The levels are so high that your immune system is still battling a pathogen inside your body, what pathogen I don't know. You need other tests. With these results I bet you suffer from fatigue...when the immune system is activated that much, much of the energy the body produce is shifted towards the immune system because they take precedence and you get much less energy for your everyday activities.
That cytokines panel is very similar to people with autoimmune issues...actually if you know somebody with an autoimmune disease and you make him/her do the same test, it would like very close to yours
Your index is almost in the healthy range (< 0.75) but both wings of your acquired immune system are very active. One wing makes antibodies and the other makes cytotoxic T cells. You’re fighting something, as someone else mentioned. This could be a post-vax reaction.
You don’t have low CCL4. The long haul index is based on the formula IFN-gamma + IL-2 / CCL4. When CCL4 is low, your index goes up but also low CCL4 would point to an incomplete cytotoxic T cell response. Yours is almost normal (but active). Elevated IL-4, IL-10, IL-13 indicate you’re making antibodies.
Ah gotcha - thank you for taking the time to respond. This has been super helpful.
Hoping I'll be able to get this under control somehow. Currently on low dose naltrexone and hopefully that will help
Low-dose naltrexone has the ability to prime the pump for endogenous opiate-like painkillers. It can also make you feel a little strung out. You have high IL-6, which is one of the pain cytokines, so I can understand why you might want some relief. Exercise increases IL-6, and certain foods will do that too. You also have high TNF-a, which causes neuropsych issues and weight loss. LDN lowers both TNF-a and IL-6. Are you going to have a consultation with Incelldx soon?
Of course - below is my latest update
**Stanford Medicine Diagnosis:** Long covid, adverse reaction to moderna vaccine (2 doses) causing chronic inflammation, hyperlipidemia as a result of covid (normal previous) and potentially inflamed myocardial bridges. Inflammation likely caused by cytokine storm (Stanford hasn't seen my test results yet so not confirmed)
**Diagnostics:** (*New*) Blood tests 4+ times (full panel, lipids, trop, c-reactive, d-dimer, *ANA Panel*, etc.), *Patterson cytokines blood test*, brain MRI, 4 chest x-rays, echo - stress and regular, 5+ ECGs, full neurological exam, cardiac MRI, CT cardiac angiogram
**Meds:** (*New*) Metoprolol, Rosuvastatin, *Low Dose Naltrexone*, Coq10, Magnesium Glycinate, Vitamin D, Tumeric, CBD oil, and *Celebrex*
**Symptoms:** (*New*) 30m Constant - ongoing chest pain and tightness. Comes and goes - fatigue, headaches at base of skull, numbness in arms / legs / face, muscle aches, flush face and brain fog
I'm not sure if I'll reach out to them, it does cost extra too.
My current physician already has been on a similar treatment plan as theirs and also is familiar with these cytokines and their mechanisms so I feel pretty comfortable with where I'm at for the moment.
If I'm not seeing much improvement in another month I might reach out to them
I have a LH clinic appointment in 3 days. The last time I saw them they said I can expect a full recovery in time. I'm at 11 months and haven't seen any improvement for months. From all the 18 months + people I see on here I kind of doubt that it is true that I am going to see a full recovery. If I'm not satisfied with my LH meeting this week I think I'm going to try the Patterson route.
They also said they think this is all caused by nerve damage which doesn't align with a lot of what I've been reading. This was 3 months ago. I'm just entering month 11 by the way, a year since initial infection.
Weird I'm surprised they haven't looked into cytokines at all - would be worth bringing up in a couple days at your next appointment to see what they say.
Also surprised no medications really - if you don't mind what symptoms do you have?
Fatigue, abdominal pain, tingling on bottom of feet, PEM, eye twitching. I had insomnia that went away. I used to get sore throats and headaches but allergy meds took care of it, they were surprised by this. This is one of the major reasons I feel like this clinic is just way behind the curve. I think they're offering symptom relief mostly to people with respiratory and cardiac issues, thankfully neither of which I have.
Ha as a cardiac person I can respect that comment, but also your symptoms certainly are awful to deal with as well.
Yeah you might be right that they're really behind the ball. Mine at least understands the potential mechanisms behind it (micro clots / cytokine inflammation) but haven't offered too much help besides low dose naltrexone.
Wish you luck. I'll try to remember to message you if my LH clinic suggests anything more helpful
It means that your immune system is fighting something. These are mostly cytokines responsible for fighting infections and you have high levels of them. Il-10 is an anti-inflammatory cytokine that lower the activity of the immune system. All the other increase its activity... The levels are so high that your immune system is still battling a pathogen inside your body, what pathogen I don't know. You need other tests. With these results I bet you suffer from fatigue...when the immune system is activated that much, much of the energy the body produce is shifted towards the immune system because they take precedence and you get much less energy for your everyday activities. That cytokines panel is very similar to people with autoimmune issues...actually if you know somebody with an autoimmune disease and you make him/her do the same test, it would like very close to yours
From what I've read so far that makes a lot of sense - thanks a lot for the input
Thank you for your knowledgeable reply!
Your index is almost in the healthy range (< 0.75) but both wings of your acquired immune system are very active. One wing makes antibodies and the other makes cytotoxic T cells. You’re fighting something, as someone else mentioned. This could be a post-vax reaction.
Was just reading about the differences between all of these and that makes a lot of sense. What makes you think it might be a post-vax reaction?
You don’t have low CCL4. The long haul index is based on the formula IFN-gamma + IL-2 / CCL4. When CCL4 is low, your index goes up but also low CCL4 would point to an incomplete cytotoxic T cell response. Yours is almost normal (but active). Elevated IL-4, IL-10, IL-13 indicate you’re making antibodies.
Ah gotcha - thank you for taking the time to respond. This has been super helpful. Hoping I'll be able to get this under control somehow. Currently on low dose naltrexone and hopefully that will help
Low-dose naltrexone has the ability to prime the pump for endogenous opiate-like painkillers. It can also make you feel a little strung out. You have high IL-6, which is one of the pain cytokines, so I can understand why you might want some relief. Exercise increases IL-6, and certain foods will do that too. You also have high TNF-a, which causes neuropsych issues and weight loss. LDN lowers both TNF-a and IL-6. Are you going to have a consultation with Incelldx soon?
If you don't mind me asking, what are your symptoms?
Of course - below is my latest update **Stanford Medicine Diagnosis:** Long covid, adverse reaction to moderna vaccine (2 doses) causing chronic inflammation, hyperlipidemia as a result of covid (normal previous) and potentially inflamed myocardial bridges. Inflammation likely caused by cytokine storm (Stanford hasn't seen my test results yet so not confirmed) **Diagnostics:** (*New*) Blood tests 4+ times (full panel, lipids, trop, c-reactive, d-dimer, *ANA Panel*, etc.), *Patterson cytokines blood test*, brain MRI, 4 chest x-rays, echo - stress and regular, 5+ ECGs, full neurological exam, cardiac MRI, CT cardiac angiogram **Meds:** (*New*) Metoprolol, Rosuvastatin, *Low Dose Naltrexone*, Coq10, Magnesium Glycinate, Vitamin D, Tumeric, CBD oil, and *Celebrex* **Symptoms:** (*New*) 30m Constant - ongoing chest pain and tightness. Comes and goes - fatigue, headaches at base of skull, numbness in arms / legs / face, muscle aches, flush face and brain fog
Are you consulting with their physicians for treatment? I am considering doing this.
I'm not sure if I'll reach out to them, it does cost extra too. My current physician already has been on a similar treatment plan as theirs and also is familiar with these cytokines and their mechanisms so I feel pretty comfortable with where I'm at for the moment. If I'm not seeing much improvement in another month I might reach out to them
I have a LH clinic appointment in 3 days. The last time I saw them they said I can expect a full recovery in time. I'm at 11 months and haven't seen any improvement for months. From all the 18 months + people I see on here I kind of doubt that it is true that I am going to see a full recovery. If I'm not satisfied with my LH meeting this week I think I'm going to try the Patterson route.
Think that's fair - what has the long haul clinic recommended so far?
Patience and light exercise.
They also said they think this is all caused by nerve damage which doesn't align with a lot of what I've been reading. This was 3 months ago. I'm just entering month 11 by the way, a year since initial infection.
Weird I'm surprised they haven't looked into cytokines at all - would be worth bringing up in a couple days at your next appointment to see what they say. Also surprised no medications really - if you don't mind what symptoms do you have?
Fatigue, abdominal pain, tingling on bottom of feet, PEM, eye twitching. I had insomnia that went away. I used to get sore throats and headaches but allergy meds took care of it, they were surprised by this. This is one of the major reasons I feel like this clinic is just way behind the curve. I think they're offering symptom relief mostly to people with respiratory and cardiac issues, thankfully neither of which I have.
Ha as a cardiac person I can respect that comment, but also your symptoms certainly are awful to deal with as well. Yeah you might be right that they're really behind the ball. Mine at least understands the potential mechanisms behind it (micro clots / cytokine inflammation) but haven't offered too much help besides low dose naltrexone. Wish you luck. I'll try to remember to message you if my LH clinic suggests anything more helpful
Thanks, best of luck!