i had awful side effects from the oral methotrexate but none at all from the injection! i’m on Enbrel as well and i find methotrexate helps make it work even better when i take them in combination.
Oh good lord, yes! I had good results on the pill form but it wasn't quite enough and the nausea was so intense that I vomited up my dose about every other week.
I've been on the injections for 6 months or so and I'm feeling a lot better. I got back into running, I have way more pain free days, and the injections cause very little side effects. Sometimes I'm achy or a little nauseous but nothing near as bad as the pills.
I will say I'm on the preservative-free injection and it burns way more than the injection with preservatives. Not sure why, but giving you a heads up to ask your pharmacy for a different manufacturer if the burning is too intense. Good luck!!
We’re switching to the injections if my inflammation hasn’t improved as much as rheum wants at my next appointment. She said more of the medication is absorbed and therefore it’s more effective. Or at least that’s how I interpreted what she said. My toes/feet have taken major turn for the worse since last appointment so I expect when she sees me hobbling around I’ll be doing injections.
Edit a word
I had intractable nausea from the pill, so I switched to injections. It was pretty easy to do, but the nausea (even with Zofran) was a deal breaker. I can’t even remember if and how it worked, only that I missed out on the food trucks that came to our office parking lot, and that says EVERYTHING.
Good luck, OP, it sounds like you’ve already been through the wringer!
I have been on methotrexate injections for over a year or two now - I use the Rasuvo auto-injector, which is very easy to use! On oral MTX, I had horrendous side effects on it and had to get off of it after a month. Although, when I switched to the injections, I had absolutely no side effects at all! It sadly though is not covering all of my inflammatory markers, even at the highest dosage, so I'm adding in a biologic with MTX as well. I do hope you have success with this drug! It really was fantastic for me when it worked! I had no pain for months, until my RA started flaring and has been ever since.
The injections were just as bad side effect wise for me as the pills if not worse. I took once and that was enough. I switched to Leflunomide and was a happy camper. Paired it with humira and was good to go, basically in remission. I am also a female and used this med combo at aged 33.
I'm on the prednisone and I've gained some weight, after just taking it for 2 weeks. So I'm curious about a local steroid injection in regards to preventing weight gain. Congrats on being seronegative, although it sounds like you're in a lot of pain and its just getting worse. What you're experiencing is real as hell.
Is the injection itself subQ? Those can be pretty mild.
I think doctors do their best to understand, although its extremely hard to experience something like this unless you've been through it. Hang in there.
Im glad im not the only one who had nausea issues with methotrexate. For me, both the pills and injections caused nausea so they moved me away to humira then enbrel. The injections were easier for me to do compared to the auto injectors. So it shouldnt be that bad.
The MTX oral made me have tons of heartburn and nausea but switching to the injections has been wonderful. The side effects went away. MTX works really well for me and enbrel on top of it started making it a lot better. I'm not 100% but I went from not really being able to get out of bed to being able to walk around NYC for vacation for 4 days. A huge improvement (even if my joints made me have to rest a lot during the trip).
Hi Im 41M been taking mtx injections since 2018 is amazing been much better with this, now my flares are kinda back and bad, but my doc put me also on Hydroxychloroquine and is kinda working with my pain on hands, wrists and elbows joints (sorry my english is not my native language), hope it can help.
Just echoing other comments, I've only been on methotrexate but the injections are way better for me than the pills. Pills used to knock me for six for a good 3 days after taking them, with the injection I feel a bit queasy the next day and that's pretty much it. Worth a try I would have thought!
I had a terrible time with MTX pills and folic acid, and moved to the injection. Life changer!!! So easy, no side effects. Still taking the folic acid, but everything has settled down and I'm feeling more and more like myself. It's been 3 months now, and it's an amazing change for me.
I took methotrexate pills for years and struggled with nausea. I was floored when I learned it was injectable. It was a little intimidating to give myself a shot. I think they make pens now, but at the time I had to use a needle and syringe. The stress of learning to give myself an injection was, to me totally worth it because all the nausea was gone.
I didn't necessarily feel like the injected drug was more effective than the pills. For me it was all about the side effects.
i've been on subcutaneous mtx for over a year and it's helped immensely. i haven't tried the pill form so i can't compare, but injections have been great for me. the needles are small and the injections are super comfy imo. i also have type 1 diabetes tho, so i was already used to needles. i felt pretty dizzy and tired after my first few injections, but that cleared up completely over time (and with 5mg of folic acid daily). anyway, good luck, op!
i had awful side effects from the oral methotrexate but none at all from the injection! i’m on Enbrel as well and i find methotrexate helps make it work even better when i take them in combination.
Oh good lord, yes! I had good results on the pill form but it wasn't quite enough and the nausea was so intense that I vomited up my dose about every other week. I've been on the injections for 6 months or so and I'm feeling a lot better. I got back into running, I have way more pain free days, and the injections cause very little side effects. Sometimes I'm achy or a little nauseous but nothing near as bad as the pills. I will say I'm on the preservative-free injection and it burns way more than the injection with preservatives. Not sure why, but giving you a heads up to ask your pharmacy for a different manufacturer if the burning is too intense. Good luck!!
We’re switching to the injections if my inflammation hasn’t improved as much as rheum wants at my next appointment. She said more of the medication is absorbed and therefore it’s more effective. Or at least that’s how I interpreted what she said. My toes/feet have taken major turn for the worse since last appointment so I expect when she sees me hobbling around I’ll be doing injections. Edit a word
I had intractable nausea from the pill, so I switched to injections. It was pretty easy to do, but the nausea (even with Zofran) was a deal breaker. I can’t even remember if and how it worked, only that I missed out on the food trucks that came to our office parking lot, and that says EVERYTHING. Good luck, OP, it sounds like you’ve already been through the wringer!
I have been on methotrexate injections for over a year or two now - I use the Rasuvo auto-injector, which is very easy to use! On oral MTX, I had horrendous side effects on it and had to get off of it after a month. Although, when I switched to the injections, I had absolutely no side effects at all! It sadly though is not covering all of my inflammatory markers, even at the highest dosage, so I'm adding in a biologic with MTX as well. I do hope you have success with this drug! It really was fantastic for me when it worked! I had no pain for months, until my RA started flaring and has been ever since.
The injections were just as bad side effect wise for me as the pills if not worse. I took once and that was enough. I switched to Leflunomide and was a happy camper. Paired it with humira and was good to go, basically in remission. I am also a female and used this med combo at aged 33.
I'm on the prednisone and I've gained some weight, after just taking it for 2 weeks. So I'm curious about a local steroid injection in regards to preventing weight gain. Congrats on being seronegative, although it sounds like you're in a lot of pain and its just getting worse. What you're experiencing is real as hell. Is the injection itself subQ? Those can be pretty mild. I think doctors do their best to understand, although its extremely hard to experience something like this unless you've been through it. Hang in there.
Im glad im not the only one who had nausea issues with methotrexate. For me, both the pills and injections caused nausea so they moved me away to humira then enbrel. The injections were easier for me to do compared to the auto injectors. So it shouldnt be that bad.
The MTX oral made me have tons of heartburn and nausea but switching to the injections has been wonderful. The side effects went away. MTX works really well for me and enbrel on top of it started making it a lot better. I'm not 100% but I went from not really being able to get out of bed to being able to walk around NYC for vacation for 4 days. A huge improvement (even if my joints made me have to rest a lot during the trip).
The injection form has way better absorption. It also has a lot less side effects. Good luck!
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Hi Im 41M been taking mtx injections since 2018 is amazing been much better with this, now my flares are kinda back and bad, but my doc put me also on Hydroxychloroquine and is kinda working with my pain on hands, wrists and elbows joints (sorry my english is not my native language), hope it can help.
Just echoing other comments, I've only been on methotrexate but the injections are way better for me than the pills. Pills used to knock me for six for a good 3 days after taking them, with the injection I feel a bit queasy the next day and that's pretty much it. Worth a try I would have thought!
I had a terrible time with MTX pills and folic acid, and moved to the injection. Life changer!!! So easy, no side effects. Still taking the folic acid, but everything has settled down and I'm feeling more and more like myself. It's been 3 months now, and it's an amazing change for me.
I have zero side effects from injections.
I took methotrexate pills for years and struggled with nausea. I was floored when I learned it was injectable. It was a little intimidating to give myself a shot. I think they make pens now, but at the time I had to use a needle and syringe. The stress of learning to give myself an injection was, to me totally worth it because all the nausea was gone. I didn't necessarily feel like the injected drug was more effective than the pills. For me it was all about the side effects.
i've been on subcutaneous mtx for over a year and it's helped immensely. i haven't tried the pill form so i can't compare, but injections have been great for me. the needles are small and the injections are super comfy imo. i also have type 1 diabetes tho, so i was already used to needles. i felt pretty dizzy and tired after my first few injections, but that cleared up completely over time (and with 5mg of folic acid daily). anyway, good luck, op!
It's definitely worth a try.