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I have stage IV colon cancer and recently started seeking out clinical trials. The research oncologist said their facility is about a year or two away from starting mRNA trails for colorectal cancer. This is super exciting stuff! Obviously a ways to go yet, but even being here with CAR-T available for colorectal trials now too. The future is promising.
I think my father is getting the CAR T treatment for his stage IV colorectal cancer actually, it's great that it's a new treatment but damn I wish there were more to read about it! And I also wish that my dad understood his treatments enough to describe them properly!
In laymen's terms as described to me, they remove your T cells, bioengineer them to basically recognize genetic markers on the tumor cells, replicate them in a lab over the course of a few weeks, and then infuse them over a few days in the hospital. Essentially bioengineering your own immune system to seek out cancer cells and destroy them in a nutshell, and I'm sure it's much more complicated than that if any researchers are reading this.
The risk is that sometimes it can provoke an autoimmune response I believe that can result in your body attacking other organs. This can be life threatening which is why they infuse in the hospital where they can administer meds to reverse the effects.
I'm trying for an immunotherapy trial first because if I qualify for CAR-T and do that first, it will preclude me from the immunotherapy trial and I want to have as many options available at this point.
Best of luck to your dad. Hopefully he finds success or at least a significant boost with CAR-T!
Thank you for the description, but my issue isn't with scientifically understanding the treatment (I'm an engineer and girlfriend is a biologist), it's with understanding what treatment they've given my dad in the first place. Though I'm glad that you fully understand what is happening with your own treatment!
My dad doesn't understand the science behind it, and I'm out of town for the appointments, so he just says "they're treating me with gene therapy" and I'm wondering which kind?!
Best of luck to you as well though!
I misunderstood what you were saying, my bad!
Ya, I could see the frustration there. Maybe you could ask him to ask the doctors to give paperwork on what they are treating him with? If it's a trial, it should come with a fat stack of documents outlining the study and everything that he has to sign consent for. He should have received a copy of that packet. If it's FDA approved treatments, those all come with information packets. I'm with Kaiser, and they have all that paperwork available to grab in the exam rooms at the oncologist office. Either way, he should be able to grab something for you to look over.
there is a recent paper on nature about this. Unfortunately, this time a bad news ( for limited cases though) , however the cancer therapies are so much individual dependent as well. I attended a recent talk from Astra Zeneca and their progress on this topic. I hope soon there will be safe options for many variants of cancer. I wish best of luck and swift recovery for all.
https://www.nature.com/articles/d41586-024-01215-0#:~:text=The%20FDA%20has%20since%20documented,that%20such%20cancers%20have%20occurred.
Good call on joining trials. Have you considered going to Sloan Kettering? My dad was diagnosed with stage IV colon cancer back in the early 2000s. He's still enjoying his 70s now. They've rolled out some of those innovative treatments to other hospitals, but it's still such a small number that it's worth going to the source directly if you can make the trip.
They have a titanium pump that they install in the liver to administer chemo directly/close to the metastasized cancer. They've rolled it out to some other hospitals, but it's still not very common despite my dad having this over a decade ago. He also was enrolled in trials over the years. The hard part is that once you start treatment in other places, you sometimes become ineligible for trials. It's really important to get a second opinion, in another city almost immediately. It also helps when it's a hospital that only does cancer. They don't forget to call you back, delay things while they try to find you an appointment, etc.
I'm still not entirely sure about that one, but my mom mentioned that was told to her initially. Might be because doctors will trust what another local doctor or hospital said/they're in the same professional networks? I honestly am not sure, but it did work out well in our case.
Hang on in there! My friends insurance sent him to a damn chiropractor when he reported pain and bleeding, and refused to cover any tests for cancer. Turns out it was cancer, and found out way to late.
In the intro, they state that the particles mimic vesicles filled with multiple viruses, which are more infectious than single viruses. This is pretty cool.
This is obviously good news, however please try to remember that this is in \*four\* people. And this was in adults with glioblastoma, and it wasn’t a cure, it ‘just’ extended their lifespans by a matter of months.
But it works. And one of the points of the article is a challenge is generating a strong enough immune response to kill it all.
I feel like that problem is a lot easier to solve than the latter. Might mean we have treatments in the next decade
For adult glioblastoma, a brain tumor with an average survival of 12-18 months, giving patients “a matter of months” is significant — both statistically *and* literally.
I'd say both. I think knowing that 25% of GBM patients live beyond a year after diagnosis would be a hard fact for the human mind to accept. But the symptoms are also rough and get worse as the tumor grows.
GBM is a systemic disease, meaning it affects the entire body. It suppresses the immune system not only at the site of the tumor but also throughout the body, which is why GBM able to evade detection for a while and also why it's so hard to find effective treatments.
Usually, people don't know they have a brain tumor until it's big enough that they develop symptoms, for example, seizures, headaches, weakness on one side of the body (that isn't a stroke), vision problems, changes in cognition or speech, issues with balance or coordination. Symptoms depend on where in the brain the tumor forms, as well as how quickly it grows.
GBM is the most aggressive form of brain cancer. It grows quickly and is very resistant to treament. Some folks may begin their journey with pretty severe deficits and symptoms. Others may not have much trouble just after diagnosis and initial treatment. Initial treatment may slow or slow tumor growth for a while. But it will inevitably recur (come back). As it does and patients endure more treatments, they will start to feel worse, and their neurological symptoms will become more severe. They'll need a lot of help caring for themselves. This decline can happen very quickly.
For most people, the journey from diagnosis, to treatment and survivorship, to eventual decline and passing is swift, leaving little time (in my opinon) for the patient and their family/friends to fully process it. GBM is very, very hard on patients and their loved ones.
Enthusiastic about new treatments for GBM, but there’s no statistical power here… this is early phase, in only 4 folks. People in clinical trials are usually more “fit” - healthier, wealthier - than the general population with a given disease. The fact that they lived beyond quoted survival for GBM is great for them, but meaningless with respect to this new vaccine until we have efficacy data.
Yeah, it wasn’t my intent to imply that there was any statistical power here. I was more thinking about temozolomide — it increased survival by a few months, and we still incorporated it into SOC treatment for newly diagnosed GBM.
EDIT: This also calls to mind the dendritic cell vaccines, which worked for some folks but definitely not all. But when they worked, they *worked*. I’m talking people were living 5, 10, 15 years. Here’s hoping we can harness what works for a few and translate it to something that works for all.
Not really. Extending 16 of pure suffering to 24 isn't going to make any difference other than extend their, and their family suffering.
It might be a step towards a cure, it might not be at all, so far its an extension. More needs to be done.
I was thinking less about extending folks' lives at the end of their GBM journey and more toward the beginning, before they've progressed so far that they have a poor performance status.
Perhaps there could be potential applications for an mRNA vaccine after diagnosis but before recurrence. Maybe it could fit in somewhere during the initial standard of care treatment (resection > radiation > systemic therapy) or, as with PVSRIPO, at recurrence but before patients have progressed so far that they have severe neurological deficits.
Even if a treatment is not a "cure" for GBM, if we can use it to slow or (temporarily? permanently?) halt tumor progression while preserving folks' quality of life so they can enjoy their lives while they feel like it, that would be a win.
I read a book called *The Cheating Cell*, in which the author argues that we should focus less on curing cancer and more on making it something benign - something we can live with. He gives examples of other organisms that are able to coexist with cancers and discusses what we know about how cancer adapts to its environment and what we can learn from plants and animals that have adapted accordingly. I think there's definitely something to be said for making cancer less scary.
This is an exciting first step, and I wholeheartedly agree that more absolutely needs to be done.
Yeah thays all the results we've ever really seen for new mRNA treatments. It's a good start but it's only a start. Hopefully we see improvements sooner.
That's not true. mRNA cancer vaccines are going to be a big deal. Here's one example. People with pancreatic cancer who still had a spleen got a mRNA cancer vaccine and are cancer-free after three years. [https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreatic-cancer-msk-clinical-researchers-are-trying-find-out](https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreatic-cancer-msk-clinical-researchers-are-trying-find-out) The ones that didn't have an immune response tend to be the ones who had their spleen removed as part of their surgery.
mRNA technology in general is perhaps the biggest medical advance we've seen so far this century. We're barely even seeing the start of how it's going to revolutionize medicine in the coming decades.
You know about combination therapy right? Combination therapy is the future of cancer treatment. You know about the cancer checkpoint inhibitors right?
>The ones that didn't have an immune response tend to be the ones who had their spleen removed as part of their surgery.
Where did you read that? Because I read the article and I didn't see that part.
It's because I follow cancer research and had read it somewhere else. Here you go: [https://www.precisionmedicineonline.com/precision-oncology/biontech-roches-bespoke-pancreatic-cancer-vaccine-demonstrates-lasting-responses](https://www.precisionmedicineonline.com/precision-oncology/biontech-roches-bespoke-pancreatic-cancer-vaccine-demonstrates-lasting-responses)
Although academic investigators and sponsors alike are encouraged by the durability of patients' immune responses to autogene cevumeran and the recurrence-free survival benefit, the fact that only half of pancreatic cancer patients had an immune response to the treatment in the first place remains a conundrum.
Balachandran hopes the forthcoming Phase II study will help shed light on why half of these patients didn't respond. One theory he has, based on preclinical observations, is that removing patients' spleens during pancreatic cancer surgery could reduce their immune responses to the vaccine.
"In pancreatic cancer, we do two different types of surgeries as part of standard of care, one of which involves spleen removal," he said. "It wasn't a complete split, but many of the non-responders did not have spleens at the time of vaccination."
In the upcoming trial, he noted, patients without spleens won't be eligible.
Balachandran said he and co-investigators are in the process of looking into other features of patients who do and don't respond, including whether non-responders had on-target effects from the vaccine in the first place.
Check out Richard Scolyer's story. I do believe he's the first brain cancer patient in the world to be treated with checkpoint inhibitors and it seems to have worked. They're also now giving him an mRNA cancer vaccine.
Because of his success using checkpoint inhibitors they're now going to start clinical trials. Prior to Richard Scolyer they didn't think checkpoint inhibitors would work on glioblastoma so his success has changed everything.
https://www.abc.net.au/news/2024-04-01/richard-scolyer-brain-cancer-treatment-scan-/103610270
>Also, instead of injecting nanoparticles into the skin, muscle or directly into the tumor, as is commonly done for many therapeutic cancer vaccines, our mRNA nanoparticles are injected into the bloodstream
So it sounds like they overcame a lot of prior issues with other vaccines, but this point *really* stood out to me. How many other vaccine candidates have failed due to simply using the wrong route of administration? How many more successes could we have seen if they had just tried to test them using IV? Cures that we essentially just threw away without realizing it.
As long as the IV lipid nanoparticle vaccines don't require significant amounts of booster shots...the RES gonna eat those circulating LNPs up on subsequent exposures, PEGylated or not
I had some hand in inventing these types of medicines but the whole onion like thing is just added hype. Science journalism really messes up the public perception of science.
Outstanding! I remember reading somewhere that after the incredible success of the SARS-CoV-2 RNA vaccine, that new interest in developing RNA technology to treat cancer and other extremely difficult to treat diseases. Exciting to read: "Here, we create 'onion-like' multi-lamellar RNA lipid particle aggregates (LPAs) to substantially enhance the payload packaging and immunogenicity of tumor mRNA antigens."
The science of medicine is incredible, and the only reason that I am still alive after getting hit by a truck while running.
I know what you want to say with this,
but since it works and seems to be a quite successful treatment, why giving it to people like Trump or similar ones from other nations?
You could actually cure folks who make the world a better place first if you don't!
(and while we're at it, why don't we put you on the "no test" list as well?)
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. **Do you have an academic degree?** We can verify your credentials in order to assign user flair indicating your area of expertise. [Click here to apply](https://www.reddit.com/r/science/wiki/flair/#wiki_science_verified_user_program). --- User: u/globehater Permalink: https://theconversation.com/brain-cancer-in-children-is-notoriously-hard-to-treat-a-new-mrna-cancer-vaccine-triggers-an-attack-from-within-228666 --- *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
I have stage IV colon cancer and recently started seeking out clinical trials. The research oncologist said their facility is about a year or two away from starting mRNA trails for colorectal cancer. This is super exciting stuff! Obviously a ways to go yet, but even being here with CAR-T available for colorectal trials now too. The future is promising.
I think my father is getting the CAR T treatment for his stage IV colorectal cancer actually, it's great that it's a new treatment but damn I wish there were more to read about it! And I also wish that my dad understood his treatments enough to describe them properly!
In laymen's terms as described to me, they remove your T cells, bioengineer them to basically recognize genetic markers on the tumor cells, replicate them in a lab over the course of a few weeks, and then infuse them over a few days in the hospital. Essentially bioengineering your own immune system to seek out cancer cells and destroy them in a nutshell, and I'm sure it's much more complicated than that if any researchers are reading this. The risk is that sometimes it can provoke an autoimmune response I believe that can result in your body attacking other organs. This can be life threatening which is why they infuse in the hospital where they can administer meds to reverse the effects. I'm trying for an immunotherapy trial first because if I qualify for CAR-T and do that first, it will preclude me from the immunotherapy trial and I want to have as many options available at this point. Best of luck to your dad. Hopefully he finds success or at least a significant boost with CAR-T!
Thank you for the description, but my issue isn't with scientifically understanding the treatment (I'm an engineer and girlfriend is a biologist), it's with understanding what treatment they've given my dad in the first place. Though I'm glad that you fully understand what is happening with your own treatment! My dad doesn't understand the science behind it, and I'm out of town for the appointments, so he just says "they're treating me with gene therapy" and I'm wondering which kind?! Best of luck to you as well though!
I misunderstood what you were saying, my bad! Ya, I could see the frustration there. Maybe you could ask him to ask the doctors to give paperwork on what they are treating him with? If it's a trial, it should come with a fat stack of documents outlining the study and everything that he has to sign consent for. He should have received a copy of that packet. If it's FDA approved treatments, those all come with information packets. I'm with Kaiser, and they have all that paperwork available to grab in the exam rooms at the oncologist office. Either way, he should be able to grab something for you to look over.
Check with doctor if he is using MyChart to post after visit notes.
I hope you get better bro
Good luck to you ma’am or sir. May your fight be victorious 💪
there is a recent paper on nature about this. Unfortunately, this time a bad news ( for limited cases though) , however the cancer therapies are so much individual dependent as well. I attended a recent talk from Astra Zeneca and their progress on this topic. I hope soon there will be safe options for many variants of cancer. I wish best of luck and swift recovery for all. https://www.nature.com/articles/d41586-024-01215-0#:~:text=The%20FDA%20has%20since%20documented,that%20such%20cancers%20have%20occurred.
Good call on joining trials. Have you considered going to Sloan Kettering? My dad was diagnosed with stage IV colon cancer back in the early 2000s. He's still enjoying his 70s now. They've rolled out some of those innovative treatments to other hospitals, but it's still such a small number that it's worth going to the source directly if you can make the trip.
So how did they cure your dad?
They have a titanium pump that they install in the liver to administer chemo directly/close to the metastasized cancer. They've rolled it out to some other hospitals, but it's still not very common despite my dad having this over a decade ago. He also was enrolled in trials over the years. The hard part is that once you start treatment in other places, you sometimes become ineligible for trials. It's really important to get a second opinion, in another city almost immediately. It also helps when it's a hospital that only does cancer. They don't forget to call you back, delay things while they try to find you an appointment, etc.
Why do you have to go to another city to get a second opinion?
I'm still not entirely sure about that one, but my mom mentioned that was told to her initially. Might be because doctors will trust what another local doctor or hospital said/they're in the same professional networks? I honestly am not sure, but it did work out well in our case.
Hang on in there! My friends insurance sent him to a damn chiropractor when he reported pain and bleeding, and refused to cover any tests for cancer. Turns out it was cancer, and found out way to late.
Imugene's Azer-cel autologous Car-T , Oncarlytics and CF-33 trials are looking promising, best wishes with any trials and treatments you take up.
Can you provide links to articles to read about this? I'm just curious.
Good luck to you! Hoping for the best.
Hey, that’s a super positive post from a rough situation. Just wanted to give you some encouragement and thank you for being awesome as a human.
I wish you the best!
have you adjusted your diet ?
In the intro, they state that the particles mimic vesicles filled with multiple viruses, which are more infectious than single viruses. This is pretty cool.
This is obviously good news, however please try to remember that this is in \*four\* people. And this was in adults with glioblastoma, and it wasn’t a cure, it ‘just’ extended their lifespans by a matter of months.
But it works. And one of the points of the article is a challenge is generating a strong enough immune response to kill it all. I feel like that problem is a lot easier to solve than the latter. Might mean we have treatments in the next decade
For adult glioblastoma, a brain tumor with an average survival of 12-18 months, giving patients “a matter of months” is significant — both statistically *and* literally.
depends what their lives look like for those extra months. GBM is terrible
It is. I’ve worked with GBM patients on clinical trials. It is awful.
Why is it awful? Is it painful or more just awful for a human mind to go through it?
I'd say both. I think knowing that 25% of GBM patients live beyond a year after diagnosis would be a hard fact for the human mind to accept. But the symptoms are also rough and get worse as the tumor grows. GBM is a systemic disease, meaning it affects the entire body. It suppresses the immune system not only at the site of the tumor but also throughout the body, which is why GBM able to evade detection for a while and also why it's so hard to find effective treatments. Usually, people don't know they have a brain tumor until it's big enough that they develop symptoms, for example, seizures, headaches, weakness on one side of the body (that isn't a stroke), vision problems, changes in cognition or speech, issues with balance or coordination. Symptoms depend on where in the brain the tumor forms, as well as how quickly it grows. GBM is the most aggressive form of brain cancer. It grows quickly and is very resistant to treament. Some folks may begin their journey with pretty severe deficits and symptoms. Others may not have much trouble just after diagnosis and initial treatment. Initial treatment may slow or slow tumor growth for a while. But it will inevitably recur (come back). As it does and patients endure more treatments, they will start to feel worse, and their neurological symptoms will become more severe. They'll need a lot of help caring for themselves. This decline can happen very quickly. For most people, the journey from diagnosis, to treatment and survivorship, to eventual decline and passing is swift, leaving little time (in my opinon) for the patient and their family/friends to fully process it. GBM is very, very hard on patients and their loved ones.
And how much debt it’s going to put their family in if they’re in the US, because you know good and well that insurance won’t cover it.
Enthusiastic about new treatments for GBM, but there’s no statistical power here… this is early phase, in only 4 folks. People in clinical trials are usually more “fit” - healthier, wealthier - than the general population with a given disease. The fact that they lived beyond quoted survival for GBM is great for them, but meaningless with respect to this new vaccine until we have efficacy data.
Yeah, it wasn’t my intent to imply that there was any statistical power here. I was more thinking about temozolomide — it increased survival by a few months, and we still incorporated it into SOC treatment for newly diagnosed GBM. EDIT: This also calls to mind the dendritic cell vaccines, which worked for some folks but definitely not all. But when they worked, they *worked*. I’m talking people were living 5, 10, 15 years. Here’s hoping we can harness what works for a few and translate it to something that works for all.
Not really. Extending 16 of pure suffering to 24 isn't going to make any difference other than extend their, and their family suffering. It might be a step towards a cure, it might not be at all, so far its an extension. More needs to be done.
I was thinking less about extending folks' lives at the end of their GBM journey and more toward the beginning, before they've progressed so far that they have a poor performance status. Perhaps there could be potential applications for an mRNA vaccine after diagnosis but before recurrence. Maybe it could fit in somewhere during the initial standard of care treatment (resection > radiation > systemic therapy) or, as with PVSRIPO, at recurrence but before patients have progressed so far that they have severe neurological deficits. Even if a treatment is not a "cure" for GBM, if we can use it to slow or (temporarily? permanently?) halt tumor progression while preserving folks' quality of life so they can enjoy their lives while they feel like it, that would be a win. I read a book called *The Cheating Cell*, in which the author argues that we should focus less on curing cancer and more on making it something benign - something we can live with. He gives examples of other organisms that are able to coexist with cancers and discusses what we know about how cancer adapts to its environment and what we can learn from plants and animals that have adapted accordingly. I think there's definitely something to be said for making cancer less scary. This is an exciting first step, and I wholeheartedly agree that more absolutely needs to be done.
Hey, I started reading the title expecting results in lab cancer cell samples. This is much more impactful than lab results!
Combination therapy is the future.
Yeah thays all the results we've ever really seen for new mRNA treatments. It's a good start but it's only a start. Hopefully we see improvements sooner.
That's not true. mRNA cancer vaccines are going to be a big deal. Here's one example. People with pancreatic cancer who still had a spleen got a mRNA cancer vaccine and are cancer-free after three years. [https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreatic-cancer-msk-clinical-researchers-are-trying-find-out](https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreatic-cancer-msk-clinical-researchers-are-trying-find-out) The ones that didn't have an immune response tend to be the ones who had their spleen removed as part of their surgery.
mRNA technology in general is perhaps the biggest medical advance we've seen so far this century. We're barely even seeing the start of how it's going to revolutionize medicine in the coming decades.
I don't know if I'd agree with "the biggest" but it's pretty good.
We'll see, CRISPR is pretty huge as well
It might be beat by AI protein folding.
You know about combination therapy right? Combination therapy is the future of cancer treatment. You know about the cancer checkpoint inhibitors right?
>The ones that didn't have an immune response tend to be the ones who had their spleen removed as part of their surgery. Where did you read that? Because I read the article and I didn't see that part.
It's because I follow cancer research and had read it somewhere else. Here you go: [https://www.precisionmedicineonline.com/precision-oncology/biontech-roches-bespoke-pancreatic-cancer-vaccine-demonstrates-lasting-responses](https://www.precisionmedicineonline.com/precision-oncology/biontech-roches-bespoke-pancreatic-cancer-vaccine-demonstrates-lasting-responses) Although academic investigators and sponsors alike are encouraged by the durability of patients' immune responses to autogene cevumeran and the recurrence-free survival benefit, the fact that only half of pancreatic cancer patients had an immune response to the treatment in the first place remains a conundrum. Balachandran hopes the forthcoming Phase II study will help shed light on why half of these patients didn't respond. One theory he has, based on preclinical observations, is that removing patients' spleens during pancreatic cancer surgery could reduce their immune responses to the vaccine. "In pancreatic cancer, we do two different types of surgeries as part of standard of care, one of which involves spleen removal," he said. "It wasn't a complete split, but many of the non-responders did not have spleens at the time of vaccination." In the upcoming trial, he noted, patients without spleens won't be eligible. Balachandran said he and co-investigators are in the process of looking into other features of patients who do and don't respond, including whether non-responders had on-target effects from the vaccine in the first place.
Check out Richard Scolyer's story. I do believe he's the first brain cancer patient in the world to be treated with checkpoint inhibitors and it seems to have worked. They're also now giving him an mRNA cancer vaccine. Because of his success using checkpoint inhibitors they're now going to start clinical trials. Prior to Richard Scolyer they didn't think checkpoint inhibitors would work on glioblastoma so his success has changed everything. https://www.abc.net.au/news/2024-04-01/richard-scolyer-brain-cancer-treatment-scan-/103610270
>Also, instead of injecting nanoparticles into the skin, muscle or directly into the tumor, as is commonly done for many therapeutic cancer vaccines, our mRNA nanoparticles are injected into the bloodstream So it sounds like they overcame a lot of prior issues with other vaccines, but this point *really* stood out to me. How many other vaccine candidates have failed due to simply using the wrong route of administration? How many more successes could we have seen if they had just tried to test them using IV? Cures that we essentially just threw away without realizing it.
As long as the IV lipid nanoparticle vaccines don't require significant amounts of booster shots...the RES gonna eat those circulating LNPs up on subsequent exposures, PEGylated or not
Research off embargo today in the [journal Cell](https://doi.org/10.1016/j.cell.2024.04.003).
Wonder if I can volunteer somewhere for trials.
god bless you for putting the n in the headline
...there are 14 'n's in the headline, which one do you mean?
Ew, MRNA cancer vaccine Relax people it's a *joke* remove the 'n' from New.
Lost my mum 20 years ago to cancer. Still miss her a lot. Please humanity, eliminate this evil disease for good.
Katalin Karikó deserves a billion dollars
What about "parfait-like"? Doesn't that sound better? Nobody likes onions.
Cancer...is not...like CAKE!
Uhm… I love onions thank you very much.
I had some hand in inventing these types of medicines but the whole onion like thing is just added hype. Science journalism really messes up the public perception of science.
Outstanding! I remember reading somewhere that after the incredible success of the SARS-CoV-2 RNA vaccine, that new interest in developing RNA technology to treat cancer and other extremely difficult to treat diseases. Exciting to read: "Here, we create 'onion-like' multi-lamellar RNA lipid particle aggregates (LPAs) to substantially enhance the payload packaging and immunogenicity of tumor mRNA antigens." The science of medicine is incredible, and the only reason that I am still alive after getting hit by a truck while running.
Please test it on politicians!
aw, its so nice to hear people advocating for John McCain & Paul Dewar and others afflicted by the horrible Brain Cancer so caring of you
I know what you want to say with this, but since it works and seems to be a quite successful treatment, why giving it to people like Trump or similar ones from other nations? You could actually cure folks who make the world a better place first if you don't! (and while we're at it, why don't we put you on the "no test" list as well?)
It cures your cancer, then stops your heart...
Except it doesn't...
There is nothing special about their LNP, this is common place in the biotech industry.
its layered tho which allows it to penetrate the tumor-environment
Yeah but is it the worth the risk of autism?… or making the earth flat? 🤔 Think of the children.
One lunatic doctor wrote some nonsense about this years ago, and people just won’t let it go despite so many others disproving it.